CLDN11

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2010]

Description

Claudin 11

Tissue specificity

Group enriched (brain, ovary, testis)

Subcell location

Lipid droplets, Cell Junctions

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (170418868 - 170454733)

Ensembl ID

ENSG00000013297  (ver. 103.38)

Orthologs

Mouse Cldn11: ENSMUSG00000037625

UniProt

O75508

neXtProt

NX_O75508

Human splice variants
Mouse splice variants

Protein structure