MASP2

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate A and B chains that heterodimerize to form the mature protease. This protease cleaves complement components C2 and C4 in order to generate C3 convertase in the lectin pathway of the complement system. The encoded protease also plays a role in the coagulation cascade through cleavage of prothrombin to form thrombin. Myocardial infarction and acute stroke patients exhibit reduced serum concentrations of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Description

Mannan binding lectin serine peptidase 2

Tissue specificity

Tissue enriched (liver)

Subcell location

Golgi apparatus

Predicted location

Secreted to blood

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (11026523 - 11047239)

Ensembl ID

ENSG00000009724  (ver. 103.38)

Orthologs

Mouse Masp2: ENSMUSG00000028979

UniProt

O00187

neXtProt

NX_O00187

Human splice variants
Mouse splice variants

Protein structure