ADA2

This gene encodes a member of a subfamily of the adenosine deaminase protein family. The encoded protein is one of two adenosine deaminases found in humans, which regulate levels of the signaling molecule, adenosine. The encoded protein is secreted from monocytes undergoing differentiation and may regulate cell proliferation and differentiation. This gene may be responsible for some of the phenotypic features associated with cat eye syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Description

Adenosine deaminase 2

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Intracellular, Secreted to blood

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (17178790 - 17258235)

Ensembl ID

ENSG00000093072  (ver. 103.38)

Orthologs

-

UniProt

Q9NZK5

neXtProt

NX_Q9NZK5

Human splice variants

Protein structure