15880-1-AP

antibody from Proteintech Group

Targeting: TDO2 TDO, TPH2

Provider product page for 15880-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
Comments [0]
Validations [0]

Submit

Product number: 15880-1-AP - Provider product page
Provider: Proteintech Group
Product name: TDO2 antibody
Antibody type: Polyclonal
Description: KD/KO validated TDO2 antibody (Cat. #15880-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TDO2 protein structure - 15880-1-AP shown in red.

Submitted references Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

Bowman CE, Neinast MD, Jang C, Patel J, Blair MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z
bioRxiv : the preprint server for biology 2024 Mar 10;

Bisphenol F exposure induces depression-like changes: Roles of the kynurenine metabolic pathway along the "liver-brain" axis.

Yu Z, Lin Y, Wu L, Wang L, Fan Y, Xu L, Zhang L, Wu W, Tao J, Huan F, Liu W, Wang J, Gao R
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123356

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804

DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.

Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Ting-Li, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
The Journal of nutritional biochemistry 2023 May;115:109282

Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through control of cell heme allocation by nitric oxide.

Biswas P, Stuehr DJ
The Journal of biological chemistry 2023 Jun;299(6):104753

Expression of Tryptophan Metabolism Enzymes in Patients with Diffuse Large B-cell Lymphoma and NK/T-cell Lymphoma.

Guo D, Wang Y, Wu X, Gao Y, Wang A, Zhang Z, Zhao K, Wang X, Liu M, Zhang Y, Li M, Chen R, Sun J, Zhang Y
Cancer medicine 2023 Jun;12(11):12139-12148

Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target.

Wang R, Yang YM
World journal of cardiology 2023 Jun 26;15(6):293-308

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway.

Liang X, Du W, Huang L, Xiang L, Pan W, Yang F, Zheng F, Xie Y, Geng L, Gong S, Xu W
Cell communication and signaling : CCS 2023 Jun 16;21(1):141

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.

Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval AJ, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Bulun SE, Wei JJ, Yue F, Adli M
Nature communications 2023 Jul 10;14(1):4057

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.

Buyukcelebi K, Chen X, Abdula F, Duval A, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Wei JJ, Bulun S, Yue F, Adli M
Research square 2023 Feb 9;

Tryptophan metabolism enzymes are potential targets in ovarian clear cell carcinoma.

Zhang S, Gao Y, Wang P, Wang S, Wang Y, Li M, Wang A, Zhao K, Zhang Z, Sun J, Guo D, Liang Z
Cancer medicine 2023 Dec;12(24):21996-22005

Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice.

Sato M, Okuno A, Ishisono K, Yajima Y, Toyoda A
International journal of tryptophan research : IJTR 2022;15:11786469221128697

DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.

Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Li T, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
Frontiers in immunology 2022;13:1089200

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Kim YS, Ko B, Kim DJ, Tak J, Han CY, Cho JY, Kim W, Kim SG
Nature communications 2022 Oct 14;13(1):6080

The Immunological Contribution of a Novel Metabolism-Related Signature to the Prognosis and Anti-Tumor Immunity in Cervical Cancer.

Yu S, Li X, Ma M, Yang R, Zhang J, Wu S
Cancers 2022 May 13;14(10)

Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.

Hutchinson AP, Yin P, Neale I, Coon JS 5th, Kujawa SA, Liu S, Bulun SE
Reproductive sciences (Thousand Oaks, Calif.) 2022 Mar;29(3):743-749

TDO2 modulates liver cancer cell migration and invasion via the Wnt5a pathway.

Liu H, Xiang Y, Zong QB, Dai ZT, Wu H, Zhang HM, Huang Y, Shen C, Wang J, Lu ZX, Ponnambalam S, Chen K, Wu Y, Zhang TC, Liao XH
International journal of oncology 2022 Jun;60(6)

Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.

Chang Y, Han P, Wang Y, Jia C, Zhang B, Zhao Y, Li S, Li S, Wang X, Yang X, Wei W
British journal of pharmacology 2022 Jun;179(12):3024-3042

High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis.

Rong G, Zhang T, Xu Y, Zhang Z, Gui B, Hu K, Zhang J, Tang Z, Shen C
BMC musculoskeletal disorders 2022 Jun 22;23(1):604

Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.

Zhang Y, Li Y, Chen X, Chen X, Chen C, Wang L, Dong X, Wang G, Gu R, Li F, Han F, Chen D
Journal of medicinal chemistry 2022 Aug 25;65(16):11214-11228

The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.

Mudhish EA, Siddique AB, Ebrahim HY, Abdelwahed KS, King JA, El Sayed KA
Nutrients 2022 Apr 4;14(7)

Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans.

Wyckelsma VL, Trepci A, Schwieler L, Venckunas T, Brazaitis M, Kamandulis S, Paulauskas H, Gapeyeva H, Pääsuke M, Gastaldello S, Imbeault S, Westerblad H, Erhardt S, Andersson DC
Antioxidants (Basel, Switzerland) 2021 Sep 10;10(9)

Tryptophan catabolism is dysregulated in leiomyomas.

Chuang TD, Quintanilla D, Boos D, Khorram O
Fertility and sterility 2021 Oct;116(4):1160-1171

Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy.

DeVito NC, Sturdivant M, Thievanthiran B, Xiao C, Plebanek MP, Salama AKS, Beasley GM, Holtzhausen A, Novotny-Diermayr V, Strickler JH, Hanks BA
Cell reports 2021 May 4;35(5):109071

Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.

Tan B, Chen J, Qin S, Liao C, Zhang Y, Wang D, Li S, Zhang Z, Zhang P, Xu F
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768

A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.

Li S, Li S, Zhao Y, Zhang B, Wang X, Yang X, Wang Y, Jia C, Chang Y, Wei W
Transgenic research 2021 Dec;30(6):781-797

Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.

Ebokaiwe AP, Njoya EM, Sheng Y, Zhang Z, Li S, Zhou Z, Qiang Z, Peng T, Hussein AA, Zhang G, Lu X, Li L, Wang F
Toxicology and applied pharmacology 2020 Oct 1;404:115203

Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO).

Zhang S, Guo L, Yang D, Xing Z, Li W, Kuang C, Yang Q
Bioorganic chemistry 2020 Nov;104:104348

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).

Pan S, Zhou Y, Wang Q, Wang Y, Tian C, Wang T, Huang L, Nan J, Li L, Yang S
European journal of medicinal chemistry 2020 Dec 1;207:112703

The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis.

Liang H, Chen M, Qi F, Shi L, Duan Z, Yang R, He J, Lou B, Li Y, Yang Q
Signal transduction and targeted therapy 2019;4:23

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.

Hughey CC, James FD, Wang Z, Goelzer M, Wasserman DH
Molecular metabolism 2019 May;23:1-13

Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.

Zhang S, Qi F, Fang X, Yang D, Hu H, Huang Q, Kuang C, Yang Q
European journal of medicinal chemistry 2018 Dec 5;160:133-145

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N
Cancer cell 2014 Dec 8;26(6):826-839

No comments: Submit comment

No validations: Submit validation data