15880-1-AP

antibody from Proteintech Group

Targeting: TDO2 TDO, TPH2

Provider product page for 15880-1-AP

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Immunohistochemistry

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Antigen structure
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Product number: 15880-1-AP - Provider product page
Provider: Proteintech Group
Product name: TDO2 antibody
Antibody type: Polyclonal
Description: KD/KO validated TDO2 antibody (Cat. #15880-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

TDO2 protein structure - 15880-1-AP shown in red.

Submitted references TDO2-Associated Tryptophan Metabolism Correlates with Impaired Tertiary Lymphoid Structure Maturation and Reduced B Cell Class Switching in Breast Cancer.

Yang W, Xiao W, Xu W, Ren L, Li X, Yu J, Wang R
Oncology research 2026;34(3):26

Elucidate senescence-related gene signature and immune infiltration landscape in abdominal aortic aneurysm.

Li J, Ying R, Luo J, Guo X, Zhang M
PloS one 2026;21(1):e0340976

AhR-Siglec-15 axis regulates lysosomal Ca2+ release for sonic hedgehog medulloblastoma growth via TRPML1.

Wang Z, Li S, Sun X, Wang D, Zhou Y, Zhou L, Chen J, Zhou N, Zhu Q, Liu J, Zhang G, Tong WM, Lv J, Huang B
Protein & cell 2026 May 1;17(5):438-451

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR-Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma.

Wang Z, Xu W, Zhao L, Zhong L, Yu W, Wang S, Sun L, Guo T, Li F, Li Z, Fang L, Wang S, Zhang G, Xue G, Guo W, Zhao S, Gu C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(13):e13606

A novel photosensitizer-based photodynamic therapy reprograms the Kynurenine-AhR axis to boost antitumor immunity in breast cancer.

Liu Y, Hong G, Liu T, Liu H
Redox biology 2026 Jun;93:104171

Effects of Dendrobium officinale on chronic fatigue in rats: Modulation of tryptophan metabolism.

Yan M, Shi M, Li C, Yu B, Zhou H, Su J, Yu J, Lv G, Chen S
Journal of ethnopharmacology 2026 Jun 28;365:121527

A step-by-step guide to performing cancer metabolism research using custom-made media.

Seifert S, Yanqui-Rivera F, Kühn T, Høyland LE, Borteçen T, Agranovich B, Eckhardt LE, Herdt M, Henneberg A, Panitz V, Hayat F, Migaud M, Poschet G, Abramovich I, Gottlieb E, Krijgsveld J, Ziegler M, Prentzell MT, Opitz CA
Life science alliance 2026 Feb;9(2)

Circadian tryptophan metabolism contributes to systemic aryl hydrocarbon receptor activity.

Morgan EW, Murray IA, Coslo DM, Patterson AD, Perdew GH
iScience 2026 Feb 20;29(2):114680

Artemether and Euphorbia factor L9 suppress kynurenine production through distinct effects on tryptophan metabolism.

Capatina AL, Czechowski T, Plunkett-Jones C, Tonon T, Kourtzelis I, Lichman BR, Brackenbury WJ, Graham IA, Lagos D
The Biochemical journal 2026 Apr 8;483(4):541-564

3-hydroxykynurenine increase in kynurenine pathway driven bisphenol F induced anxiety- and depression-like behaviors.

Lin Y, Wang L, Meng S, Liu J, Li X, Wang W, Hu M, Wang X, Duan W, Xu S, Wang J, Gao R
The Science of the total environment 2025 Sep 15;995:180073

Huo Po Xia Ling decoction exerts preventive and improvement effects on gastric precancerous lesions by remodeling gut microbiota and associated metabolites.

Song Y, Qiao Y, Gao S, Cao M, Shan Y, Mao J, Chi X, Chang L, Shan B, Huo B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157131

Quercetin inhibits gastric cancer cell proliferation and migration and is associated with the suppression of the IDO1-Kynurenine-AhR axis.

Zhu M, Hu Q, Lu Y, Xu Q, Huang H, Chen K, Shuai X, Wang Y, Huang J, Guo Z
BMC cancer 2025 Nov 25;25(1):1916

Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures.

Tang Z, Bai Y, Fang Q, Yuan Y, Zeng Q, Chen S, Xu T, Chen J, Tan L, Wang C, Li Q, Lin J, Yang Z, Wu X, Shi G, Wang J, Yin C, Guo J, Liu S, Peng S, Kuang M
Cancer cell 2025 Jun 9;43(6):1025-1044.e14

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

Bowman CE, Neinast MD, Kawakami R, Forelli N, Jang C, Patel J, Blair MC, Noji MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z
Molecular metabolism 2025 Jul;97:102165

Kai-Xin-San ameliorates fluoxetine-resistant depressive-like behaviors by modulating tryptophan-kynurenine metabolic homeostasis in a rodent model.

Yao L, Jing R, Wang C, Wang Y, Li X, Wu X, Wang Y, Liu L, Mu L, Liu P, Hu Y
Journal of ethnopharmacology 2025 Jul 24;351:120011

Discovery of (E)-2-cyano-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)-3-(1H-indol-3-yl)acrylamide as a novel TDO inhibitor for cancer treatment.

Wang X, Wang X, Wang X, Xu K, Long J, Chen Y, Liu Y, Niu H, Zeng B, Fan Y
Bioorganic chemistry 2025 Jul 1;161:108555

Tissue accumulation and hepatotoxicity of 8:2 chlorinated polyfluoroalkyl ether sulfonate: A multi-omics analysis deciphering hepatic amino acid metabolic dysregulation in mice.

Tan Z, An Z, Lv J, Xiao F, Li L, Li J, Duan W, Guo M, Zeng X, Liu Y, Li A, Guo H
Journal of hazardous materials 2025 Feb 5;483:136668

Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia.

Lewczuk A, Boratyńska-Jasińska A, Charzewski Ł, Beręsewicz-Haller M, Zabłocka B
Pharmacological reports : PR 2025 Dec;77(6):1639-1656

Evaluation of the clinical characteristics and potentially prognostic factors in HER2-positive breast cancer.

Shi L, Xi PW, Li Z, Wu J, Zhang X, Zhang L
Amino acids 2025 Dec 16;58(1):4

SIRPA, BTN3A1, and TDO2 in osteosarcoma: a prognostic triad with therapeutic implications from integrated genomic and pharmacogenomic data.

Zhang HJ, Yang ZJ, Huang W, Chen D, Xiang J, Chen WK
Journal of orthopaedic surgery and research 2025 Aug 7;20(1):742

AR to GR switch modulates differential TDO2-Kyn-AhR signalling to promote the survival and recurrence of treatment-induced dormant cells in prostate cancer.

Li S, Zhang Y, Luo M, Zhou W, Chen Y, Wu D, Wei Q, Chang Y, Hu H
Cell discovery 2025 Aug 5;11(1):67

Circulating proteins and metabolites panel for noninvasive preoperative diagnosis of epithelial ovarian cancer.

Jia Y, Yuan L, Wen W, Chen L, Zhao X, Wu Q, Liao Y, Shao C, Pan C, Zhang C, Yao S
BMC medicine 2025 Aug 22;23(1):492

3-Hydroxypropionaldehyde modulates tryptophan metabolism to activate AhR signaling and alleviate ethanol-induced liver injury.

Liu C, Wang Y, Sheng L, Zhang Y, Luo G, Ruan XZ, Chen Y, Huang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156445

Lactobacillus Johnsonii YH1136 alleviates schizophrenia-like behavior in mice: a gut-microbiota-brain axis hypothesis study.

Zheng L, Xin J, Ye H, Sun N, Gan B, Gong X, Bao S, Xiang M, Wang H, Ni X, Li H, Zhang T
BMC microbiology 2025 Apr 2;25(1):191

Establishment of a prognostic model for hypoxia-associated genes in OPSCC and revelation of intercellular crosstalk.

Zhao Y, Yu J, Zheng C, Zhou B
Frontiers in immunology 2024;15:1371365

Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction.

Liu Y, Chen S, Wan X, Wang R, Luo H, Chang C, Dai P, Gan Y, Guo Y, Hou Y, Sun Y, Teng Y, Cui X, Liu M
Cancer communications (London, England) 2024 Nov;44(11):1261-1286

PET Imaging of Neurofibromatosis Type 1 with a Fluorine-18 Labeled Tryptophan Radiotracer.

Yue X, Stauff E, Boyapati S, Langhans SA, Xu W, Makrogiannis S, Okorie UJ, Okorie AM, Kandula VVR, Kecskemethy HH, Nikam RM, Averill LW, Shaffer TH
Pharmaceuticals (Basel, Switzerland) 2024 May 27;17(6)

Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK.

Bowman CE, Neinast MD, Jang C, Patel J, Blair MC, Mirek ET, Jonsson WO, Chu Q, Merlo L, Mandik-Nayak L, Anthony TG, Rabinowitz JD, Arany Z
bioRxiv : the preprint server for biology 2024 Mar 10;

In Vivo Effects of Bay 11-7082 on Fibroid Growth and Gene Expression: A Preclinical Study.

Chuang TD, Ton N, Rysling S, Khorram O
Cells 2024 Jun 24;13(13)

Reprogrammed IDO-Induced Immunosuppressive Microenvironment Synergizes with Immunogenic Magnetothermodynamics for Improved Cancer Therapy.

Wang X, Yan B, Li H, Yuan J, Guo J, Wang S, Dai P, Liu X
ACS applied materials & interfaces 2024 Jun 19;16(24):30671-30684

Bisphenol F exposure induces depression-like changes: Roles of the kynurenine metabolic pathway along the "liver-brain" axis.

Yu Z, Lin Y, Wu L, Wang L, Fan Y, Xu L, Zhang L, Wu W, Tao J, Huan F, Liu W, Wang J, Gao R
Environmental pollution (Barking, Essex : 1987) 2024 Apr 1;346:123356

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y, Kaya I, Shariatgorji R, Lundkvist J, Wahlberg LU, Nilsson A, Mamula D, Kehr J, Zareba-Paslawska J, Biverstål H, Chergui K, Zhang X, Andren PE, Svenningsson P
Nature communications 2023 Sep 19;14(1):5804

DSS-induced acute colitis causes dysregulated tryptophan metabolism in brain: an involvement of gut microbiota.

Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Ting-Li, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
The Journal of nutritional biochemistry 2023 May;115:109282

Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through control of cell heme allocation by nitric oxide.

Biswas P, Stuehr DJ
The Journal of biological chemistry 2023 Jun;299(6):104753

Expression of Tryptophan Metabolism Enzymes in Patients with Diffuse Large B-cell Lymphoma and NK/T-cell Lymphoma.

Guo D, Wang Y, Wu X, Gao Y, Wang A, Zhang Z, Zhao K, Wang X, Liu M, Zhang Y, Li M, Chen R, Sun J, Zhang Y
Cancer medicine 2023 Jun;12(11):12139-12148

Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target.

Wang R, Yang YM
World journal of cardiology 2023 Jun 26;15(6):293-308

Helicobacter pylori promotes gastric intestinal metaplasia through activation of IRF3-mediated kynurenine pathway.

Liang X, Du W, Huang L, Xiang L, Pan W, Yang F, Zheng F, Xie Y, Geng L, Gong S, Xu W
Cell communication and signaling : CCS 2023 Jun 16;21(1):141

Engineered MED12 mutations drive leiomyoma-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.

Buyukcelebi K, Chen X, Abdula F, Elkafas H, Duval AJ, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Bulun SE, Wei JJ, Yue F, Adli M
Nature communications 2023 Jul 10;14(1):4057

Engineered MED12 mutations drive uterine fibroid-like transcriptional and metabolic programs by altering the 3D genome compartmentalization.

Buyukcelebi K, Chen X, Abdula F, Duval A, Ozturk H, Seker-Polat F, Jin Q, Yin P, Feng Y, Wei JJ, Bulun S, Yue F, Adli M
Research square 2023 Feb 9;

Tryptophan metabolism enzymes are potential targets in ovarian clear cell carcinoma.

Zhang S, Gao Y, Wang P, Wang S, Wang Y, Li M, Wang A, Zhao K, Zhang Z, Sun J, Guo D, Liang Z
Cancer medicine 2023 Dec;12(24):21996-22005

Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice.

Sato M, Okuno A, Ishisono K, Yajima Y, Toyoda A
International journal of tryptophan research : IJTR 2022;15:11786469221128697

DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota.

Zhao LP, Wu J, Quan W, Zhou Y, Hong H, Niu GY, Li T, Huang SB, Qiao CM, Zhao WJ, Cui C, Shen YQ
Frontiers in immunology 2022;13:1089200

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Kim YS, Ko B, Kim DJ, Tak J, Han CY, Cho JY, Kim W, Kim SG
Nature communications 2022 Oct 14;13(1):6080

The Immunological Contribution of a Novel Metabolism-Related Signature to the Prognosis and Anti-Tumor Immunity in Cervical Cancer.

Yu S, Li X, Ma M, Yang R, Zhang J, Wu S
Cancers 2022 May 13;14(10)

Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.

Hutchinson AP, Yin P, Neale I, Coon JS 5th, Kujawa SA, Liu S, Bulun SE
Reproductive sciences (Thousand Oaks, Calif.) 2022 Mar;29(3):743-749

TDO2 modulates liver cancer cell migration and invasion via the Wnt5a pathway.

Liu H, Xiang Y, Zong QB, Dai ZT, Wu H, Zhang HM, Huang Y, Shen C, Wang J, Lu ZX, Ponnambalam S, Chen K, Wu Y, Zhang TC, Liao XH
International journal of oncology 2022 Jun;60(6)

Tryptophan 2,3-dioxygenase 2 plays a key role in regulating the activation of fibroblast-like synoviocytes in autoimmune arthritis.

Chang Y, Han P, Wang Y, Jia C, Zhang B, Zhao Y, Li S, Li S, Wang X, Yang X, Wei W
British journal of pharmacology 2022 Jun;179(12):3024-3042

High levels of TDO2 in relation to pro-inflammatory cytokines in synovium and synovial fluid of patients with osteoarthritis.

Rong G, Zhang T, Xu Y, Zhang Z, Gui B, Hu K, Zhang J, Tang Z, Shen C
BMC musculoskeletal disorders 2022 Jun 22;23(1):604

Discovery of 1-(Hetero)aryl-β-carboline Derivatives as IDO1/TDO Dual Inhibitors with Antidepressant Activity.

Zhang Y, Li Y, Chen X, Chen X, Chen C, Wang L, Dong X, Wang G, Gu R, Li F, Han F, Chen D
Journal of medicinal chemistry 2022 Aug 25;65(16):11214-11228

The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.

Mudhish EA, Siddique AB, Ebrahim HY, Abdelwahed KS, King JA, El Sayed KA
Nutrients 2022 Apr 4;14(7)

Vitamin C and E Treatment Blocks Changes in Kynurenine Metabolism Triggered by Three Weeks of Sprint Interval Training in Recreationally Active Elderly Humans.

Wyckelsma VL, Trepci A, Schwieler L, Venckunas T, Brazaitis M, Kamandulis S, Paulauskas H, Gapeyeva H, Pääsuke M, Gastaldello S, Imbeault S, Westerblad H, Erhardt S, Andersson DC
Antioxidants (Basel, Switzerland) 2021 Sep 10;10(9)

Tryptophan catabolism is dysregulated in leiomyomas.

Chuang TD, Quintanilla D, Boos D, Khorram O
Fertility and sterility 2021 Oct;116(4):1160-1171

Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy.

DeVito NC, Sturdivant M, Thievanthiran B, Xiao C, Plebanek MP, Salama AKS, Beasley GM, Holtzhausen A, Novotny-Diermayr V, Strickler JH, Hanks BA
Cell reports 2021 May 4;35(5):109071

Tryptophan Pathway-Targeted Metabolomics Study on the Mechanism and Intervention of Cisplatin-Induced Acute Kidney Injury in Rats.

Tan B, Chen J, Qin S, Liao C, Zhang Y, Wang D, Li S, Zhang Z, Zhang P, Xu F
Chemical research in toxicology 2021 Jul 19;34(7):1759-1768

A comprehensive analysis of TDO2 expression in immune cells and characterization of immune cell phenotype in TDO2 knockout mice.

Li S, Li S, Zhao Y, Zhang B, Wang X, Yang X, Wang Y, Jia C, Chang Y, Wei W
Transgenic research 2021 Dec;30(6):781-797

Salinomycin promotes T-cell proliferation by inhibiting the expression and enzymatic activity of immunosuppressive indoleamine-2,3-dioxygenase in human breast cancer cells.

Ebokaiwe AP, Njoya EM, Sheng Y, Zhang Z, Li S, Zhou Z, Qiang Z, Peng T, Hussein AA, Zhang G, Lu X, Li L, Wang F
Toxicology and applied pharmacology 2020 Oct 1;404:115203

Evaluation and comparison of the commonly used bioassays of human indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO).

Zhang S, Guo L, Yang D, Xing Z, Li W, Kuang C, Yang Q
Bioorganic chemistry 2020 Nov;104:104348

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).

Pan S, Zhou Y, Wang Q, Wang Y, Tian C, Wang T, Huang L, Nan J, Li L, Yang S
European journal of medicinal chemistry 2020 Dec 1;207:112703

The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis.

Liang H, Chen M, Qi F, Shi L, Duan Z, Yang R, He J, Lou B, Li Y, Yang Q
Signal transduction and targeted therapy 2019;4:23

Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation.

Hughey CC, James FD, Wang Z, Goelzer M, Wasserman DH
Molecular metabolism 2019 May;23:1-13

Tryptophan 2,3-dioxygenase inhibitory activities of tryptanthrin derivatives.

Zhang S, Qi F, Fang X, Yang D, Hu H, Huang Q, Kuang C, Yang Q
European journal of medicinal chemistry 2018 Dec 5;160:133-145

Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N
Cancer cell 2014 Dec 8;26(6):826-839

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