COL18A1

gene product
KNO, KNO1, KS
This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
564 antibodies from 33 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
5 antibodies
Novus Biologicals
31 antibodies
R&D Systems
5 antibodies
antibodies-online
185 antibodies
LifeSpan BioSciences, Inc.
115 antibodies
Affinity Biosciences
3 antibodies
Biorbyt
20 antibodies
NovoPro Bioscience Inc.
5 antibodies
Acris Antibodies GmbH
16 antibodies
GeneTex
7 antibodies
Aviva Systems Biology
5 antibodies
Proteintech Group
1 antibody
OriGene
13 antibodies
Abgent
5 antibodies
Atlas Antibodies
2 antibodies
Bioworld Technology, Inc
2 antibodies
Boster Biological Technology
2 antibodies
NSJ Bioreagents
1 antibody
Creative Biolabs
26 antibodies
ProSci
7 antibodies
Abnova Corporation
4 antibodies
MyBioSource
12 antibodies
St John's Laboratory
3 antibodies
RayBiotech, Inc.
3 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Abbiotec
2 antibodies
United States Biological
61 antibodies
EMD Millipore
2 antibodies
GenWay
2 antibodies
PeproTech Inc.
2 antibodies
Creative Diagnostics
2 antibodies
Sigma-Aldrich
1 antibody