COPE

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Description

COPI coat complex subunit epsilon

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (18899514 - 18919387)

Ensembl ID

ENSG00000105669  (ver. 103.38)

Orthologs

Mouse Cope: ENSMUSG00000055681

UniProt

O14579

neXtProt

NX_O14579

Human splice variants
Mouse splice variants

Protein structure