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CAD
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseGATD4
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Top validated antibodies |
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| Proteintech Group |  16617-1-AP |
7 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Invitrogen Antibodies | MA5-56509 |
Monoclonal |
WB
ICC
IP
IHC
FC
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| antibodies-online | ABIN253268 |
2 references | Polyclonal |
WB
ICC
IP
IHC
|
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| Novus Biologicals | NB100-61614 |
2 references | Polyclonal |
WB
IP
IHC
|
|
| LSBio | LS-C168267 |
Polyclonal |
WB
IHC
|
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