16617-1-AP

antibody from Proteintech Group

Targeting: CAD GATD4

Provider product page for 16617-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [17]
Comments [0]
Validations
Western blot [1]

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Product number: 16617-1-AP - Provider product page
Provider: Proteintech Group
Product name: CAD antibody
Antibody type: Polyclonal
Description: CAD antibody (Cat. #16617-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CAD protein structure - 16617-1-AP shown in red.

Submitted references Integrated multi-omics mapping of the causal landscape of gout across the circulating-tissue axis.

Huang L, Liu J, Zheng X, Zhang K, Chen Y, Chen X, Zhang S, Cai S, Cai L, Guo Y, Zhu P, Li M
Frontiers in immunology 2026;17:1776456

Mitochondrial ACSS1 links acetate metabolism to pyrimidine biosynthesis in nutrient-stressed B-cell lymphomas.

Basappa J, Goldman AR, Lobello C, Wang S, Rushmore D, Melnikov O, Sen NV, Mallikarjuna VS, Jain P, Edalati M, Nelson DS, Cai KQ, Lu P, Nejati R, Borghaei H, Gupta PK, Nath K, Wellen KE, Wasik MA
Cancer letters 2026 Jul 1;649:218488

Reduction in within-litter variation of piglet birth weight through dietary supplementation of 3-hydroxyisobutyric acid in sows.

Che L, Niu L, Liu L, Li M, Huo W, Deng H, Chen W, Pang L, Xu M
Frontiers in veterinary science 2025;12:1646332

De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma.

Xu D, Gao Y, Liu S, Yin S, Hu T, Deng H, Zhang T, Hegedüs B, Marti TM, Dorn P, Liang SQ, Schmid RA, Peng RW, Shu Y
EMBO molecular medicine 2025 Sep;17(9):2258-2298

Targeting CAD with a tumor microenvironment-responsive nano-heterojunction for synergistic induction of cuproptosis and inhibition of colorectal cancer progression.

Xiang Y, Liao Y, Yao M, Zhai Z, Zhao W, Zhang Y, Chen Z, Li C, Wang X, Zhang S, Li S, Zhu L, Chen J, Liu W, Xia Z, Peng J
Journal of nanobiotechnology 2025 Nov 22;23(1):746

FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression.

Zhi Y, Guo Y, Li S, He X, Wei H, Laster K, Wu Q, Zhao D, Xie J, Ruan S, Lemoine NR, Li H, Dong Z, Liu K
Cell death & disease 2025 Apr 27;16(1):348

Valine metabolite, 3-hydroxyisobutyrate, promotes lipid metabolism and cell proliferation in porcine mammary gland epithelial cells.

Che L, Liu L, Xu M, Fan Z, Niu L, Chen Y, Chang X, Zhou P, Li M, Deng H, Chen W
Frontiers in nutrition 2024;11:1524738

p53 activation enhances the sensitivity of non-small cell lung cancer to the combination of SH003 and docetaxel by inhibiting de novo pyrimidine synthesis.

Choi YJ, Lee K, Lee SY, Kwon Y, Woo J, Jeon CY, Ko SG
Cancer cell international 2024 May 4;24(1):156

Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer.

Dong S, Zhang M, Cheng Z, Zhang X, Liang W, Li S, Li L, Xu Q, Song S, Liu Z, Yang G, Zhao X, Tao Z, Liang S, Wang K, Zhang G, Hu S
Redox biology 2024 Jul;73:103207

High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.

Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, Liu R, Liu Y, Chen C, Wang K, Tang N, Huang AL
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6

De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.

Yang C, Zhao Y, Wang L, Guo Z, Ma L, Yang R, Wu Y, Li X, Niu J, Chu Q, Fu Y, Li B
Nature cell biology 2023 Jun;25(6):836-847

Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.

Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN
Metabolites 2023 Jun 21;13(7)

Identification of Key Genes Related With Aspartic Acid Metabolism and Corresponding Protein Expression in Human Colon Cancer With Postoperative Prognosis and the Underlying Molecular Pathways Prediction.

Sun W, Jia C, Zhang X, Wang Z, Li Y, Fang X
Frontiers in cell and developmental biology 2022;10:812271

Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.

Zhu Y, Yang Y, Bu H, Huang H, Chen H, Ran J, Qin L, Ni Y, Yao M, Song T, Li M, Yang Y, Guo T, Chao N, Liu Z, Li W, Zhang L
Cancer science 2022 Nov;113(11):3722-3734

Synergistic targeting of CHK1 and mTOR in MYC-driven tumors.

Song X, Wang L, Wang T, Hu J, Wang J, Tu R, Su H, Jiang J, Qing G, Liu H
Carcinogenesis 2021 Apr 17;42(3):448-460

Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription.

Zou G, Zhang X, Wang L, Li X, Xie T, Zhao J, Yan J, Wang L, Ye H, Jiao S, Xiang R, Shi Y
Theranostics 2020;10(15):6839-6853

Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway.

Lv Y, Wang X, Li X, Xu G, Bai Y, Wu J, Piao Y, Shi Y, Xiang R, Wang L
PLoS biology 2020 Nov;18(11):e3000872

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The CAD antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CAD. This antibody recognizes human antigen. The CAD antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 16617-1-AP.pdf

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