NBP1-62178

antibody from Novus Biologicals

Targeting: MAP3K8 c-COT, COT, EST, ESTF, MEKK8, Tpl-2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

NBP1-62178

Provider

Novus Biologicals

Proper citation

Novus Cat#NBP1-62178, RRID:AB_11038759

Product name

Rabbit Polyclonal MAP3K8/Tpl2/COT Antibody

Antibody type

Polyclonal

Description

MAP3K8/Tpl2/COT

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100 ug Reaction

Storage

Store at -20C. Avoid freeze-thaw cycles.

References

Submitted references

TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth.

Jeong JH, Bhatia A, Toth Z, Oh S, Inn KS, Liao CP, Roy-Burman P, Melamed J, Coetzee GA, Jung JU
PloS one 2011 Jan 18;6(1):e16205

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Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.

Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF
Diabetes 2010 Jan;59(1):61-70

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Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.

Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):7984-93

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When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.

O'Neill LA
Immunity 2008 Jul 18;29(1):12-20