Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations [0]
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- Product number
- NBP1-62178 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-62178, RRID:AB_11038759
- Product name
- Rabbit Polyclonal MAP3K8/Tpl2/COT Antibody
- Antibody type
- Polyclonal
- Description
- MAP3K8/Tpl2/COT
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 ug Reaction
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references TPL2/COT/MAP3K8 (TPL2) activation promotes androgen depletion-independent (ADI) prostate cancer growth.
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.
Jeong JH, Bhatia A, Toth Z, Oh S, Inn KS, Liao CP, Roy-Burman P, Melamed J, Coetzee GA, Jung JU
PloS one 2011 Jan 18;6(1):e16205
PloS one 2011 Jan 18;6(1):e16205
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
Jager J, Grémeaux T, Gonzalez T, Bonnafous S, Debard C, Laville M, Vidal H, Tran A, Gual P, Le Marchand-Brustel Y, Cormont M, Tanti JF
Diabetes 2010 Jan;59(1):61-70
Diabetes 2010 Jan;59(1):61-70
Tumor progression locus 2 (Map3k8) is critical for host defense against Listeria monocytogenes and IL-1 beta production.
Mielke LA, Elkins KL, Wei L, Starr R, Tsichlis PN, O'Shea JJ, Watford WT
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):7984-93
Journal of immunology (Baltimore, Md. : 1950) 2009 Dec 15;183(12):7984-93
When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction.
O'Neill LA
Immunity 2008 Jul 18;29(1):12-20
Immunity 2008 Jul 18;29(1):12-20
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