MAP3K8

gene product
c-COT, COT, EST, ESTF, MEKK8, Tpl-2
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
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552 antibodies from 33 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
21 antibodies
GeneTex
5 antibodies
Atlas Antibodies
1 antibody
antibodies-online
188 antibodies
Biorbyt
34 antibodies
Aviva Systems Biology
8 antibodies
LifeSpan BioSciences, Inc.
83 antibodies
Affinity Biosciences
3 antibodies
Abnova Corporation
8 antibodies
Invitrogen Antibodies
14 antibodies
OriGene
21 antibodies
Santa Cruz Biotechnology
1 antibody
Bioworld Technology, Inc
2 antibodies
Acris Antibodies GmbH
9 antibodies
NovoPro Bioscience Inc.
4 antibodies
Abgent
5 antibodies
NSJ Bioreagents
1 antibody
St John's Laboratory
4 antibodies
Abbkine Scientific Co.Ltd.
4 antibodies
Boster Biological Technology
2 antibodies
FabGennix
3 antibodies
ProSci
4 antibodies
MyBioSource
12 antibodies
R&D Systems
1 antibody
United States Biological
60 antibodies
RabMAbs
4 antibodies
Cell Signaling Technology, Inc
1 antibody
Creative Biolabs
5 antibodies
Sigma-Aldrich
2 antibodies
Abbexa
3 antibodies
RayBiotech, Inc.
2 antibodies
GenWay
1 antibody