ABIN358351

antibody from antibodies-online

Targeting: MAP3K8 c-COT, COT, EST, ESTF, MEKK8, Tpl-2

No application information provided.

Antibody Data

Product number

ABIN358351

Provider

antibodies-online

Product name

anti-Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8) (pThr290) antibody

Antibody type

Polyclonal

Description

Protein A Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with peptides. The antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Reactivity

Human

Host

Rabbit

Epitope

pThr290

Vial size

0.4 mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation.

Sánchez-Góngora E, Lisbona C, de Gregorio R, Ballester A, Calvo V, Pérez-Jurado L, Alemany S
The Journal of biological chemistry 2000 Oct 6;275(40):31379-86

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A rheumatoid factor transgenic mouse model of autoantibody regulation.

Shlomchik MJ, Zharhary D, Saunders T, Camper SA, Weigert MG
International immunology 1993 Oct;5(10):1329-41

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The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation.

Aoki M, Hamada F, Sugimoto T, Sumida S, Akiyama T, Toyoshima K
The Journal of biological chemistry 1993 Oct 25;268(30):22723-32

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Identification and characterization of protein products of the cot oncogene with serine kinase activity.

Aoki M, Akiyama T, Miyoshi J, Toyoshima K
Oncogene 1991 Sep;6(9):1515-9

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Structure and transforming potential of the human cot oncogene encoding a putative protein kinase.

Miyoshi J, Higashi T, Mukai H, Ohuchi T, Kakunaga T
Molecular and cellular biology 1991 Aug;11(8):4088-96