Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
BEST1
Bestrophin 1BEST, BMD, RP50, VMD2
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms. [provided by RefSeq, Nov 2008]
Top validated antibodies |
|||||
| Novus Biologicals |  NB300-164 |
33 references | Monoclonal |
WB
ICC
IP
IHC
PLA
|
|
| Invitrogen Antibodies | MA1-16739 |
2 references | Monoclonal |
WB
IP
IHC
OA
|
|
| GeneTex | GTX14927 |
1 references | Polyclonal |
WB
ICC
IP
IHC
|
|
| Antibodies.com | A51996 |
Polyclonal |
WB
EL
ICC
IP
IHC
|
||
| antibodies-online | ABIN152509 |
26 references | Monoclonal |
WB
ICC
IP
IHC
|
|
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider