Tissue expression
Cell line expression
Protein structure
CSE1L
Chromosome segregation 1 likeCAS, CSE1, XPO2
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Top validated antibodies |
|||||
GeneTex | GTX103005 | 2 references | Polyclonal |
WB
ICC
IP
IHC |
|
Novus Biologicals | H00001434-M08 | 11 references | Monoclonal |
WB
EL
ICC
IHC |
|
Abnova Corporation | H00001434-M08 | 10 references | Monoclonal |
WB
EL
ICC
IHC |
|
Proteintech Group | 22219-1-AP | 7 references | Polyclonal |
WB
EL
IP
IHC |
|
antibodies-online | ABIN560494 | 10 references | Monoclonal |
WB
EL
ICC
IHC |
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