MYPN

Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and accessory proteins required for structure and function. This gene encodes a protein which interacts with nebulin in skeletal muscle or nebulette in cardiac muscle and alpha-actinin. In addition, this gene product can interact with a protein with the I-band indicating it has a regulatory as well as structural function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Description

Myopalladin

Tissue specificity

Tissue enhanced (heart muscle, skeletal muscle, tongue)

Subcell location

Nucleoplasm, Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (68106117 - 68212017)

Ensembl ID

ENSG00000138347  (ver. 103.38)

Orthologs

Mouse Mypn: ENSMUSG00000020067

UniProt

Q86TC9

neXtProt

NX_Q86TC9

Human splice variants
Mouse splice variants

Protein structure