UBR4

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

Description

ubiquitin protein ligase E3 component n-recognin 4

Protein family

Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Predicted membrane proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

1:p36.13 (19074506 - 19210276)

Ensembl ID

ENSG00000127481  (ver. 84.38)

Orthologs

Mouse Ubr4: ENSMUSG00000066036

UniProt

Q5T4S7

neXtProt

NX_Q5T4S7

Human splice variants
Mouse splice variants