CENPI

This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016]

Description

Centromere protein I

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (101098218 - 101163681)

Ensembl ID

ENSG00000102384  (ver. 103.38)

Orthologs

Mouse Cenpi: ENSMUSG00000031262

UniProt

Q92674

neXtProt

NX_Q92674

Human splice variants
Mouse splice variants

Protein structure