ADGRE3

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Description

Adhesion G protein-coupled receptor E3

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Predicted location

Membrane, Secreted to blood

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins

Chromosome

19 (14619117 - 14690027)

Ensembl ID

ENSG00000131355  (ver. 103.38)

Orthologs

-

UniProt

Q9BY15

neXtProt

NX_Q9BY15

Human splice variants

Protein structure