12180-1-AP

antibody from Proteintech Group

Targeting: CTNND1 CTNND, KIAA0384, p120, p120cas, p120ctn

Provider product page for 12180-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 12180-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12180-1-AP, RRID:AB_2086267
Product name: p120 Catenin antibody
Antibody type: Polyclonal
Description: KD/KO validated p120 Catenin antibody (Cat. #12180-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CTNND1 protein structure - 12180-1-AP shown in red.

Submitted references Multimodal hybrid nanozymes with antioxidant catalytic and antibiotic-free antibacterial activities for enhanced multi-target sepsis therapy.

Zhu K, Zhang B, Li Y, Pan Y, Zhang S, Tang H, Yang Z, Tang X, Zhang X, Chen W, Wang Q, Ma S, Zhao L, Yao Y, Zhou H, Chen G
Cell reports. Medicine 2026 Jan 20;7(1):102541

A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure.

Yin H, Jiang H, Zhao R, Zhang Y, Fan X, Zhai X, Yang X, Zhang Y
Ecotoxicology and environmental safety 2025 Sep 1;302:118752

Downregulation of p120 catenin in the mouse hippocampus contributes to the development of depression-like phenotypes.

Chen C, Feng LP, Shi PL, Liu Q, Zhang LW, Wang Q, Hua RF, Su X, Li WQ
Behavioral and brain functions : BBF 2025 Nov 14;21(1):39

TTK Inhibition Alleviates Postinjury Neointimal Formation and Atherosclerosis.

Wu JH, Liu YX, Zong JB, Qiu M, Zhou YF, Li YN, Aili T, Zhao XR, Hu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2409250

Lactobacillus gasseri ATCC33323 affects the intestinal mucosal barrier to ameliorate DSS-induced colitis through the NR1I3-mediated regulation of E-cadherin.

Qian G, Zang H, Tang J, Zhang H, Yu J, Jia H, Zhang X, Zhou J
PLoS pathogens 2024 Sep;20(9):e1012541

The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.

Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081

Histone Deacetylase 7-Derived 7-Amino Acid Peptide Increases Skin Wound Healing via Regulating Epidermal Fibroblast Proliferation and Migration.

Liu H, Li H, Bai X, Zhao Y, Cai Y, Pan H, Guo L, Liu K, Liu Q, Huang X, Zampetaki A, Margariti A, Zeng L, Cai T
Journal of cellular and molecular medicine 2024 Nov;28(22):e70209

Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1.

Jing R, Fu M, Huang Y, Zhang K, Ye J, Gong F, Jihea Ali Naji Nasser AB, Xu X, Xiao J, Yu G, Lin S, Zhao W, Xu N, Li X, Li Z, Gao S
British journal of pharmacology 2024 Jun;181(11):1596-1613

Cannabidiol represses miR-143 to promote cardiomyocyte proliferation and heart regeneration after myocardial infarction.

Ren Z, Liu Y, Cai A, Yu Y, Wang X, Lan L, Guo X, Yan H, Gao X, Li H, Tian Y, Ji H, Chen H, Ding F, Ma W, Wang N, Cai B, Yang B
European journal of pharmacology 2024 Jan 15;963:176245

Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders.

Li W, Chen R, Feng L, Dang X, Liu J, Chen T, Yang J, Su X, Lv L, Li T, Zhang Z, Luo XJ
Nature human behaviour 2024 Feb;8(2):361-379

Frameshift variants in the C-terminal of CTNNB1 cause familial exudative vitreoretinopathy by AXIN1-mediated ubiquitin-proteasome degradation condensation.

Liu Y, Yang M, Fan L, He Y, Dai E, Liu M, Jiang L, Yang Z, Li S
International journal of biological macromolecules 2024 Feb;258(Pt 1):128570

Dynamic interactions between E-cadherin and Ankyrin-G mediate epithelial cell polarity maintenance.

Kong C, Qu X, Liu M, Xu W, Chen D, Zhang Y, Zhang S, Zhu F, Liu Z, Li J, Huang C, Wang C
Nature communications 2023 Oct 27;14(1):6860

Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions.

Tiruppathi C, Wang DM, Ansari MO, Bano S, Tsukasaki Y, Mukhopadhyay A, Joshi JC, Loch C, Niessen HWM, Malik AB
Nature communications 2023 Oct 18;14(1):6582

Overexpression of PTPRZ1 Regulates p120/β-Catenin Phosphorylation to Promote Carcinogenesis of Oral Submucous Fibrosis.

Ma L, Shen T, Peng H, Wu J, Wang W, Gao X
Journal of oncology 2022;2022:2352360

ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.

Zhang R, Xie L, Wu F, Xu J, Lu L, Cao L, Li L, Meng W, Zhang H, Shao C, Li X, Chen D
Frontiers in pharmacology 2022;13:828896

Laminin-511 Activates the Human Induced Pluripotent Stem Cell Survival via α6β1 Integrin-Fyn-RhoA-ROCK Signaling.

Nakashima Y, Tsukahara M
Stem cells and development 2022 Nov;31(21-22):706-719

Chromogranin A-derived peptide CGA47-66 protects against septic brain injury by reducing blood-brain barrier damage through the PI3K/AKT pathway.

Wang F, Zeng Y, Liu X, Cao J, Kang S, Zhou W, Chen X, Liu J, Zhang D
Biochemical and biophysical research communications 2022 May 21;605:162-170

F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model.

Liu XZ, Jin Y, Chen S, Xu K, Xie L, Qiu Y, Wang XH, Sun Y, Kong WJ
Frontiers in molecular neuroscience 2021;14:808553

NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.

Wei M, Ma Y, Shen L, Xu Y, Liu L, Bu X, Guo Z, Qin H, Li Z, Wang Z, Wu K, Yao L, Li J, Zhang J
EBioMedicine 2020 Nov;61:103068

Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy.

Wu JH, Li YN, Chen AQ, Hong CD, Zhang CL, Wang HL, Zhou YF, Li PC, Wang Y, Mao L, Xia YP, He QW, Jin HJ, Yue ZY, Hu B
EMBO molecular medicine 2020 Feb 7;12(2):e10154

Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.

Liu D, Zhang H, Cui M, Chen C, Feng Y
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927

Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways.

Cheng Z, Lei Z, Yang P, Si A, Xiang D, Tang X, Guo G, Zhou J, Hüser N
Molecular carcinogenesis 2019 Aug;58(8):1389-1399

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: RAW264.7 cells were subjected to SDS PAGE followed by western blot with 12180-1-AP(CTNND1 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using CTNND1 antibody 12180-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line