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Learn13149-1-AP
antibody from Proteintech Group
Targeting: FBXW11
BTRC2, BTRCP2, Fbw11, Fbw1b, FBXW1B, Hos, KIAA0696
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 13149-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13149-1-AP, RRID:AB_2102595
- Product name
- FBXW11 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FBXW11 antibody (Cat. #13149-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Oncogenic and immunological roles of LAMP5 across cancers and its potential utility in bladder cancer.
Orlistat targets NEDD8 conjugating enzyme UBC12 for cancer therapy.
FBXW11 inhibits tumorigenesis by ubiquitinating YB1 in hepatocarcinoma.
Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway.
E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer.
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function.
Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer.
E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer.
AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its βTrCP2-Mediated Degradation in KEAP1-Deficient Cells.
Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.
NUMB facilitates autophagy initiation through targeting SCF(β-TrCP2) complex.
A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling.
Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma.
uc.77- Downregulation Promotes Colorectal Cancer Cell Proliferation by Inhibiting FBXW8-Mediated CDK4 Protein Degradation.
MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
Role of miR-214 in regulation of β-catenin and the malignant phenotype of melanoma.
CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes.
MiR-182 promotes cell proliferation by suppressing FBXW7 and FBXW11 in non-small cell lung cancer.
The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.
The E3 ubiquitin ligase APC/C(C)(dh1) degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.
Lin Z, Zhao K, Wang S, Liu J, Liu Y, Qiang K, Huang M, Sun N, Zhang P, Hu Y, Lu Y, Jin H
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):65
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):65
Orlistat targets NEDD8 conjugating enzyme UBC12 for cancer therapy.
Shen M, Li H, Xuan Y, Zhu H, Chen L, Hao P, Zhang C, Fang J, Zhou X, Yan R, Qu Y, Ke X
Pharmacological research 2026 Apr 30;228:108214
Pharmacological research 2026 Apr 30;228:108214
FBXW11 inhibits tumorigenesis by ubiquitinating YB1 in hepatocarcinoma.
Liu W, Xu B, Wang T, Liu X, Dong C, Wang L
Journal of cancer research and clinical oncology 2025 Sep 13;151(9):256
Journal of cancer research and clinical oncology 2025 Sep 13;151(9):256
Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway.
Sun P, Chen Q, Chen X, Zhou J, Long T, Ma Y, Zhou M, Hu Z, Tian J, Zhu F, Yang Z, Xie L, Wu Q, Nie J
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167656
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167656
E3 ubiquitin ligase FBXW11-mediated downregulation of S100A11 promotes sensitivity to PARP inhibitor in ovarian cancer.
Chen L, Wang M, Gao Y, Lv Y, Zhai L, Dong J, Chen Y, Li X, Guo X, Chen B, Ru Y, Lv X
Journal of pharmaceutical analysis 2025 Jul;15(7):101246
Journal of pharmaceutical analysis 2025 Jul;15(7):101246
WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function.
Wang X, Zhu R, Yu P, Qi S, Zhong Z, Jin R, Wang Y, Gu Y, Ye D, Chen K, Shu Y, Wang Y, Yu FX
Science advances 2025 Jan 24;11(4):eadp4765
Science advances 2025 Jan 24;11(4):eadp4765
Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer.
Zhang J, Zhao K, Zhou W, Kang R, Wei S, Shu Y, Yu C, Ku Y, Mao Y, Luo H, Yang J, Mei J, Pu Q, Deng S, Zha Z, Yuan G, Shen S, Chen Y, Liu L
Signal transduction and targeted therapy 2024 Mar 9;9(1):65
Signal transduction and targeted therapy 2024 Mar 9;9(1):65
E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer.
Tan P, Cai S, Huang Z, Li M, Liu S, Chen J, Fu W, Zhao L
Cellular signalling 2024 Apr;116:111033
Cellular signalling 2024 Apr;116:111033
AMPK-Mediated Phosphorylation of Nrf2 at S374/S408/S433 Favors Its βTrCP2-Mediated Degradation in KEAP1-Deficient Cells.
Petsouki E, Ender S, Sosa Cabrera SN, Heiss EH
Antioxidants (Basel, Switzerland) 2023 Aug 9;12(8)
Antioxidants (Basel, Switzerland) 2023 Aug 9;12(8)
Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma.
Chen C, Zhou H, Zhang X, Liu Z, Ma X
Cancer biomarkers : section A of Disease markers 2022;35(4):429-437
Cancer biomarkers : section A of Disease markers 2022;35(4):429-437
NUMB facilitates autophagy initiation through targeting SCF(β-TrCP2) complex.
Li H, Shu S, Zhou M, Chen Y, Xiao A, Ma Y, Zhu F, Hu Z, Nie J
Cell death and differentiation 2022 Jul;29(7):1409-1422
Cell death and differentiation 2022 Jul;29(7):1409-1422
A yes-associated protein 1- Notch1 receptor positive feedback loop promotes breast cancer lung metastasis by attenuating the bone morphogenetic protein 4-SMAD family member 1/5 signaling.
Zhao L, Lei J, Gu S, Zhang Y, Jing X, Wang L, Zhang L, Ning Q, Luo M, Qi Y, Zhao X, Shao S
Carcinogenesis 2022 Dec 31;43(12):1162-1175
Carcinogenesis 2022 Dec 31;43(12):1162-1175
Dysregulation of Zinc Finger Protein 395 Contributes to the Pathogenesis of Chondrosarcoma.
Chen C, Zhou H, Liu Z, Ma X
OncoTargets and therapy 2021;14:3545-3553
OncoTargets and therapy 2021;14:3545-3553
uc.77- Downregulation Promotes Colorectal Cancer Cell Proliferation by Inhibiting FBXW8-Mediated CDK4 Protein Degradation.
Zheng Z, Hong D, Zhang X, Chang Y, Sun N, Lin Z, Li H, Huang S, Zhang R, Xie Q, Huang H, Jin H
Frontiers in oncology 2021;11:673223
Frontiers in oncology 2021;11:673223
MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal.
Zhang Y, Ding H, Wang X, Wang X, Wan S, Xu A, Gan R, Ye SD
Cell reports 2021 Nov 2;37(5):109949
Cell reports 2021 Nov 2;37(5):109949
Role of miR-214 in regulation of β-catenin and the malignant phenotype of melanoma.
Prabhakar K, Rodrίguez CI, Jayanthy AS, Mikheil DM, Bhasker AI, Perera RJ, Setaluri V
Molecular carcinogenesis 2019 Nov;58(11):1974-1984
Molecular carcinogenesis 2019 Nov;58(11):1974-1984
CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes.
Luo Y, Liu Y, Wu L, Ma X, Liu Q, Huang F, Zhang X, Zhang Y, Zhang J, Luo H, Yang Y, Lu G, Tang X, Li L, Zeng Y, Pan T, Zhang H
Journal of immunology (Baltimore, Md. : 1950) 2019 Jul 1;203(1):269-281
Journal of immunology (Baltimore, Md. : 1950) 2019 Jul 1;203(1):269-281
MiR-182 promotes cell proliferation by suppressing FBXW7 and FBXW11 in non-small cell lung cancer.
Chang H, Liu YH, Wang LL, Wang J, Zhao ZH, Qu JF, Wang SF
American journal of translational research 2018;10(4):1131-1142
American journal of translational research 2018;10(4):1131-1142
The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.
Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y
Nature communications 2017 Jan 16;8:14002
Nature communications 2017 Jan 16;8:14002
The E3 ubiquitin ligase APC/C(C)(dh1) degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.
Liu X, Zong W, Li T, Wang Y, Xu X, Zhou ZW, Wang ZQ
The EMBO journal 2017 Dec 15;36(24):3666-3681
The EMBO journal 2017 Dec 15;36(24):3666-3681
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligase.
Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, Wei W, Shi Y
Molecular and cellular biology 2013 Mar;33(6):1139-48
Molecular and cellular biology 2013 Mar;33(6):1139-48
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FBXW11 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FBXW11. This antibody recognizes human,mouse,rat antigen. The FBXW11 antibody has been validated for the following applications: ELISA, WB analysis.
