PLCE1

gene product
KIAA1516, NPHS3, PLCE
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
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Antibodypedia Validation Initiative

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43 antibodies from 13 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Affinity Biosciences
1 antibody
LifeSpan BioSciences, Inc.
21 antibodies
Abnova Corporation
2 antibodies
Atlas Antibodies
2 antibodies
Novus Biologicals
2 antibodies
antibodies-online
6 antibodies
Biorbyt
1 antibody
Invitrogen Antibodies
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Sigma-Aldrich
2 antibodies
Creative Diagnostics
2 antibodies
EMD Millipore
1 antibody
St John's Laboratory
1 antibody