Tissue expression
Cell line expression
Protein structure

PLCE1

Phospholipase C epsilon 1
KIAA1516, NPHS3, PLCE 
This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]
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47 antibodies from 14 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
2 antibodies
Affinity Biosciences
1 antibody
Abnova Corporation
2 antibodies
Atlas Antibodies
2 antibodies
antibodies-online
6 antibodies
Novus Biologicals
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Boster Biological Technology
1 antibody
Creative Diagnostics
2 antibodies
MilliporeSigma / Merck KGaA
2 antibodies
St John's Laboratory
1 antibody
Abbexa
2 antibodies
EMD Millipore
1 antibody