Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS5721 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- Frizzled 6 (G169) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 169-214 of Human Frizzled-6.
- Description
- Frizzled-6 (FZD6, also known as frizzled homolog 6 in Drosophila) is a seven-transmembrane domain receptor that binds the Wnt ligand and influences macroscopic hair patterning and other tissue polarity events. Frizzled-6 protein contains a signal peptide and a cysteine-rich domain (CRD) in the N-terminal extracellular region, and does not contain a C-terminal PDZ domain-binding motif. Frizzled-3 and frizzled-6 influence neural tube closure and the planar orientation of hair bundles on a subset of auditory and vestibular sensory cells. Madin-Darby canine kidney (MDCK) cells are competent to form tubules in vitro and express the frizzled-6 receptor, which is known to form a complex with Wnt-4 through the CRD in this cell type. Frizzled-6 is expressed as a 4.4 kb mRNA in various human tissues, including adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- Western blot (WB) analysis of Frizzled-6 (G169) pAb at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Raw264.7 cell lysateLane3:PC12 cell lysate