HTR2A

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Description

5-hydroxytryptamine receptor 2A

Tissue specificity

Tissue enhanced (brain, choroid plexus)

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

13 (46831546 - 46897076)

Ensembl ID

ENSG00000102468  (ver. 103.38)

Orthologs

Mouse Htr2a: ENSMUSG00000034997

UniProt

P28223

neXtProt

NX_P28223

Human splice variants
Mouse splice variants

Protein structure