KCNMB4

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

Description

Potassium calcium-activated channel subfamily M regulatory beta subunit 4

Tissue specificity

Group enriched (adrenal gland, brain, choroid plexus)

Subcell location

Cytosol

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

12 (70366290 - 70434292)

Ensembl ID

ENSG00000135643  (ver. 103.38)

Orthologs

Mouse Kcnmb4: ENSMUSG00000054934

UniProt

Q86W47

neXtProt

NX_Q86W47

Human splice variants
Mouse splice variants

Protein structure