20695-1-AP

antibody from Proteintech Group

Targeting: EP300 KAT3B, p300

ELISA (Data presented on provider website)

Antibody Data

Product number

20695-1-AP

Provider

Proteintech Group

Product name

EP300 antibody

Antibody type

Polyclonal

Description

EP300 antibody (Cat. #20695-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: ELISA.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Vascular Smooth Muscle Cell-Specific BCAT2 Deficiency Attenuates Diabetic Atherosclerotic Calcification via Histone Propionylation.

Zhang L, Yang Y, Yuan W, Dai Z, Li L, Sun Z, Shao C, Zang G, Qian Y, Wang Z
Research (Washington, D.C.) 2026;9:1052

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Curcumol Induces Necroptosis of Hepatic Stellate Cells by Targeting KAT8 to Suppress HK2 Lactylation and Promote HUWE1-Dependent Ubiquitination.

Guo X, Lin Y, Jiang Y, Wang M, Li Y, Gao Y, Chen B, Bao Z, Tian H, Chu X, Zhang Z, Shao J, Zhang F, Wang H, Xuan J, Xu X, Zheng S
International journal of biological sciences 2026;22(3):1648-1673

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Fufang Baizhi tincture protects melanocytes from oxidative stress by targeting CASP7-mediated apoptosis and EP300-associated transcriptional regulation.

Feng H, Wang Y, Sun L, Yue X, Li Y
Journal of ethnopharmacology 2026 May 10;362:121395

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NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.

Xu H, Jiang X, Wang F, Meng F, Liu Y, Huang J, Li J, Zhu M
Nature communications 2026 Mar 9;17(1)

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Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation.

Wang G, Gong G, Yang X, Qian Y, Zhao Y, Li D, Liu M, Xu Z, Zhang F
Journal of advanced research 2026 Mar 9;

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EP300/NCOA1 complex drives glioma angiogenesis via H3K27 acetylation-dependent activation of VEGFA.

Yang S, Yao X, Lin X, Yang D, Ying X
Experimental cell research 2026 Jun 1;459(1):115004

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Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma.

Li J, Xun W, Wang X, Luo R, Hu Q, Zhou Z, Yuan J, Wang Y, Wan X, Zhao T, Han T, Wang JB
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(3):e10733

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Narciclasine Alleviates Endothelial Inflammation and Atherosclerosis Initiation by Inhibiting Histone Lactylation-Mediated NF-κB Activation.

Wang Z, Zhang Z, Xin R, Ma M, Sun Z, Li Z, Zhang C, Liu L, Wu Z, Zhang Y, Chen Y
Inflammation 2026 Jan 16;49(1):49

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation.

Yu L, Zhou N, Zhang XL, Pang XJ, Xing L, Pu YJ, Zhang L, Wu JN, Shu H
Molecular medicine reports 2026 Feb;33(2)

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Histone lactylation increases CXCL1 expression for neutrophil infiltration and immune escape in pancreatic cancer.

Zhang P, Ma J, Wan Y, Li C, Liu L, He M, Zhang N, Ma Y, Hu J, Zhao L, Zhong Z, Lei X, Gong J, Zeng T, Ma J, Da Y, Zhou Z, Yang J, Wang X, Gong T, Zhang C
Nature communications 2026 Feb 9;17(1)

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EP300 promotes hepatocellular carcinoma proliferation, migration and in vivo tumorigenicity revealed by integrated experimental and bioinformatic analyses.

Liu Z, Wang J, Wu X, Shi H, Ding Y, Liu X
Journal of translational medicine 2026 Feb 4;24(1)

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Lactate Promotes Endothelial-Mesenchymal Transition via Mediating Twist1 Lactylation in Hypoxic Pulmonary Hypertension.

Li X, Wang F, Liu N, Liu Y, Yu W, Tang M
International journal of molecular sciences 2026 Feb 27;27(5)

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Discovery of Novel CBP/p300 and BRD4 Dual-Target PROTACs with Potent Antitumor Activity in Prostate Cancer.

Zhang YZ, Zhu HJ, Zhou XX, Li SJ, Han D, Liu FX, Zhou HM, Jiang XY, Guan YY, Ren HR, Wang Y, Dai WJ, Ban YB, Su N, Ma YC, Xu YT, Wang SQ, Duan YC
Journal of medicinal chemistry 2026 Feb 26;69(4):4512-4547

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Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.

Luo S, Lyu Z, Huang H, Zhao J, Li Y, Luo Y
Brain, behavior, and immunity 2026 Feb 17;135:106493

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METTL3-mediated m6A modification of TIFA mRNA promotes tubular cell pyroptosis in acute kidney injury.

Ji ML, Peng LJ, Zhu Q, Cheng XR, Suo XG, Wang F, Wei J, Wang ZJ, Sun T, Zhang MM, Wang YF, Shao BY, Guo JB, Li HD, Xie SS, Li C, Ge QL, Dong YH, Li XY, Jin J, Yu JT, Yang C, Meng XM, Chen HY, Wen JG, Wang JN
Free radical biology & medicine 2026 Feb 16;244:68-83

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EP300 attenuates ferroptosis and stimulates proliferation, migration, and fibrosis of keloid fibroblasts via YY1/GPX4 axis.

Jin J, Wang K, Lu C, Yao C, Xie F
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-16

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ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.

Tai C, Ling C, Yang Y, Mo N, Yao C, Lv S, Zhang B, Wang H, Chen C
CNS neuroscience & therapeutics 2026 Apr;32(4):e70879

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PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation.

Chen H, Huang Z, Chang R, Gao W, Qiu Y, Sun B, Hua C, Lin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e23139

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The Paeonol of Total Glucosides of White Peony Regulates the Differentiation of CD4+Treg Cells through the EP300/Foxp3 Axis to Relieve Pulmonary Fibrosis in Mice.

Yan M, Wang Q, Yang H, Liu D, Liang W, Chen H
Cell biochemistry and biophysics 2025 Sep;83(3):3959-3970

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Deacetylation of TALDO1 by HDAC6 promotes glycolysis and nasopharyngeal carcinoma progression through a moonlighting function.

Peng X, Zhou P, Zhang K, Chen L, Tang M, Zhou Q, Peng J, Yang L
Cell death & disease 2025 Oct 21;16(1):743

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Dimeric PKM2 induces ferroptosis from intestinal ischemia/reperfusion in mice by histone H4 lysine 12 lactylation-mediated HMGB1 transcription activation through the lactic acid/p300 axis.

Liu Z, Zhou Y, Li M, Xiao Z, Zhao Z, Li Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):167998

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UGDH Lactylation Aggravates Osteoarthritis by Suppressing Glycosaminoglycan Synthesis and Orchestrating Nucleocytoplasmic Transport to Activate MAPK Signaling.

Lan W, Chen X, Yu H, Ruan J, Kang J, Nie X, Cao Y, Tang S, Ding C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2413709

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NEAT1 promotes the perineural invasion of pancreatic cancer via the E2F1/GDNF axis.

Gu J, Wang Q, Mo J, Qin T, Qian W, Duan W, Han L, Wang Z, Ma Q, Ma J
Cancer letters 2025 Mar 31;613:217497

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The Ku protein family regulates hyperglycemia-induced vascular endothelial cell inflammation by modulating P300 levels.

Cai Q, Zhao Q, Yang Q, Zhu M, Meng F, Jiang J
Experimental cell research 2025 Jan 15;444(2):114399

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SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1.

Zhang Y, He F, Cai N, Chen G, Wang Y, Bai W, Guo P
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2025 Dec;41(1):2515516

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KLF13-mediated CES2 upregulation via p300-dependent acetylation sensitizes gastric cancer cells to irinotecan.

Zhang HB, Hu RH, Zhang KH, Cui XM, Zhang S
iScience 2025 Dec 19;28(12):114199

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Exercise-induced histone lactylation in monocyte-derived macrophages restores cardiac immune homeostasis and function in sepsis-induced cardiomyopathy.

Sun S, Lai C, Huang C, Ren X, Zhang T, Zou J, Tong Y, Zhou Q, Lu J, Shen Z, Chen W, Wang R, Rabrenovic N, Wang X, Ma B, Qian J, Fu G, Shang M
Nature communications 2025 Dec 15;17(1):756

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MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.

Ji X, Xue F, Wang Y, Gao D, Sun J, Dong T, Mu Q, Xu Q, Sun S, Liu Y, Wan Q
Cell death & disease 2025 Aug 26;16(1):646

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Exosome-derived circ-001422 promotes tumor-associated macrophage M2 polarization to accelerate the progression of glioma.

Cao W, Zeng Z, Sun J, Chen Y, Kuang F, Luo S, Lan J, Lei S
Communications biology 2024 Nov 13;7(1):1504

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Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma.

Zhu Y, Jian X, Chen S, An G, Jiang D, Yang Q, Zhang J, Hu J, Qiu Y, Feng X, Guo J, Chen X, Li Z, Zhou R, Hu C, He N, Shi F, Huang S, Liu H, Li X, Xie L, Zhu Y, Zhao L, Jiang Y, Li J, Wang J, Qiu L, Chen X, Jia W, He Y, Zhou W
Cell metabolism 2024 Jan 2;36(1):159-175.e8