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Cell line expression
Protein structure
EP300
E1A binding protein p300KAT3B, p300
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  NB100-616 |
14 references | Monoclonal |
WB
ICC
IP
FC
IEM
ChIP
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| Invitrogen Antibodies | MA1-16622 |
2 references | Monoclonal |
WB
ICC
IP
FC
ChIP
OA
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| R&D Systems | AF3789 |
1 references | Polyclonal |
WB
ICC
IHC
ChIP
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| GeneTex | GTX30618 |
Monoclonal |
WB
ICC
IP
FC
IEM
ChIP
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| LSBio | LS-B6081 |
Monoclonal |
WB
EL
ICC
IHC
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