SLC8A1

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation. [supplied by OMIM, Apr 2004]

Description

Solute carrier family 8 member A1

Tissue specificity

Tissue enriched (heart muscle)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

2 (40097270 - 40611053)

Ensembl ID

ENSG00000183023  (ver. 103.38)

Orthologs

Mouse Slc8a1: ENSMUSG00000054640

UniProt

P32418

neXtProt

NX_P32418

Human splice variants
Mouse splice variants

Protein structure