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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 313713 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#313713, RRID:AB_528761
- Product name
- Alexa Fluor® 700 anti-human CD195 (CCR5) [HEK/1/85a]
- Antibody type
- Monoclonal
- Antigen
- CHO cells transfected with human CCR5
- Description
- CD195, also known as CCR5, is a 45 kD G protein-coupled seven transmembrane CC-chemokine receptor. It binds to MIP-1α, MIP-1β, and RANTES and is expressed on a subset of T cells and monocytes. CD195 mediates an intracellular signal thought to induce cell differentiation and proliferation. CCR5 has also been shown to act as a co-receptor for R5 HIV-1 cell entry; modification of CCR5 by sulfation contributes to the efficiency of HIV-1 entry. Recent studies have shown CCR5 to play a role in a variety of other human diseases, ranging from infectious and inflammatory diseases to cancer.
- Reactivity
- Human
- Host
- Rat
- Conjugate
- Far-Red dye, Near infrared dye
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Elevated CD14++CD16- monocytes predict cardiovascular events.
Berg KE, Ljungcrantz I, Andersson L, Bryngelsson C, Hedblad B, Fredrikson GN, Nilsson J, Björkbacka H
Circulation. Cardiovascular genetics 2012 Feb 1;5(1):122-31
Circulation. Cardiovascular genetics 2012 Feb 1;5(1):122-31
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood lymphocytes stained with HEK/1/85a Alexa Fluor® 700
- Conjugate
- Near infrared dye
