Tissue expression
Cell line expression
Protein structure
CCR5
C-C motif chemokine receptor 5CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]
Top validated antibodies |
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R&D Systems | MAB182-100 | 22 references | Monoclonal |
ICC
FC
BN
|
|
Proteintech Group | 17476-1-AP | 6 references | Polyclonal |
WB
EL
IHC
FC |
|
antibodies-online | ABIN151963 | 2 references | Polyclonal |
WB
EL
ICC
FC
FA
|
|
OriGene | AM20421PU-N | Monoclonal |
WB
EL
IP
IHC
FC
|
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GeneTex | GTX21673 | 2 references | Polyclonal |
WB
EL
ICC
IHC |
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