ARID5B

This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Description

AT-rich interaction domain 5B

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nucleoplasm, Endoplasmic reticulum, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

10 (61901684 - 62096944)

Ensembl ID

ENSG00000150347  (ver. 103.38)

Orthologs

Mouse Arid5b: ENSMUSG00000019947

UniProt

Q14865

neXtProt

NX_Q14865

Human splice variants
Mouse splice variants

Protein structure