CDC42EP2

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]

Description

CDC42 effector protein 2

Tissue specificity

Low tissue specificity

Subcell location

Microtubules, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (65314866 - 65322417)

Ensembl ID

ENSG00000149798  (ver. 103.38)

Orthologs

Mouse Cdc42ep2: ENSMUSG00000045664

UniProt

O14613

neXtProt

NX_O14613

Human splice variants
Mouse splice variants

Protein structure