Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 60044 - Provider product page
- Provider
- STEMCELL Technologies Inc
- Product name
- Anti-Human CD73 Antibody, Clone AD2
- Antibody type
- Monoclonal
- Description
- The AD2 antibody reacts with human CD73, a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein and ecto-5-nucleotidase expressed on the surface of subsets of B and T cells, follicular dendritic cells, mesenchymal stem cells, endothelial cells, and epithelial cells. CD73 catalyzes the hydrolysis of 5-adenosine monophosphate (AMP) to form the bioactive nucleoside adenosine, and plays a pivotal role in the activation of P1 adenosine receptors by regulating extracellular adenosine concentrations. CD73 also appears to function as a co-signaling molecule on T cells and as an adhesion molecule mediating lymphocyte interactions with the endothelium and follicular dendritic cells. CD73 is used as a marker for lymphocyte differentiation, its expression increasing during development. It is also a useful marker for identifying undifferentiated mesenchymal stem cells. CD73 is highly expressed in many types of human and mouse cancers, and has been implicated in the control of tumor growth.
- Reactivity
- Human
- Isotype
- IgG
- Vial size
- 100 µg
- Storage
- 2 - 8°C
No comments: Submit comment
No validations: Submit validation data