NT5E

The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

Description

5'-nucleotidase, ecto (CD73)

Protein family

CD markers, Disease related genes, Enzymes, Mapped to UniProt SWISS-PROT, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

6:q14.3 (85449584 - 85495791)

Ensembl ID

ENSG00000135318  (ver. 84.38)

Orthologs

Mouse Nt5e: ENSMUSG00000032420

UniProt

P21589

neXtProt

NX_P21589

Human splice variants
Mouse splice variants