60044AZ

antibody from STEMCELL Technologies Inc

Targeting: NT5E CALJA, CD73, eN, eNT, NT5

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60044AZ

Provider

STEMCELL Technologies Inc

Product name

Anti-Human CD73 Antibody, Clone AD2, APC

Antibody type

Monoclonal

Description

The AD2 antibody reacts with human CD73, a glycosyl phosphatidylinositol (GPI)-anchored glycoprotein and ecto-5’-nucleotidase expressed on the surface of subsets of B and T cells, follicular dendritic cells, mesenchymal stem cells, endothelial cells, and epithelial cells. CD73 catalyzes the hydrolysis of 5’-adenosine monophosphate (AMP) to form the bioactive nucleoside adenosine, and plays a pivotal role in the activation of P1 adenosine receptors by regulating extracellular adenosine concentrations. CD73 also appears to function as a co-signaling molecule on T cells and as an adhesion molecule mediating lymphocyte interactions with the endothelium and follicular dendritic cells. CD73 is used as a marker for lymphocyte differentiation, its expression increasing during development. It is also a useful marker for identifying undifferentiated mesenchymal stem cells. CD73 is highly expressed in many types of human and mouse cancers, and has been implicated in the control of tumor growth.

Reactivity

Human

Isotype

IgG

Vial size

100 Tests

Storage

2 - 8°C