HPA017357

antibody from Atlas Antibodies

Targeting: NT5E CALJA, CD73, eN, eNT, NT5

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA017357

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA017357, RRID:AB_1846330

Product name

Anti-NT5E

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human NT5E, Gene description: 5'-nucleotidase, ecto (CD73), Alternative Gene Names: CALJA, CD73, eN, eNT, NT5, Validated applications: ICC, IHC, WB, Uniprot ID: P21589, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.4 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

The expression of the adenosine pathway markers CD39 and CD73 in salivary gland carcinomas harbors the potential for novel immune checkpoint inhibition

Bauer A, Gebauer N, Knief J, Tharun L, Arnold N, Riecke A, Steinestel K, Witte H
Journal of Cancer Research and Clinical Oncology 2022;149(7):3193-3208

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CD73-Mediated Immunosuppression Is Linked to a Specific Fibroblast Population That Paves the Way for New Therapy in Breast Cancer

Magagna I, Gourdin N, Kieffer Y, Licaj M, Mhaidly R, Andre P, Morel A, Vincent-Salomon A, Paturel C, Mechta-Grigoriou F
Cancers 2021;13(23):5878

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CD73 Promotes Tumor Progression in Patients with Esophageal Squamous Cell Carcinoma

Chen Y, Lu H, Lo C, Li S
Cancers 2021;13(16):3982

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Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma.

Alcedo KP, Guerrero A, Basrur V, Fu D, Richardson ML, McLane JS, Tsou CC, Nesvizhskii AI, Welling TH, Lebrilla CB, Otey CA, Kim HJ, Omary MB, Snider NT
Hepatology communications 2019 Oct;3(10):1400-1414

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Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers

Haun R, Quick C, Siegel E, Raju I, Mackintosh S, Tackett A
Cancer Biology & Therapy 2015;16(10):1557-1565

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Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

Häusler S, Montalbán del Barrio I, Strohschein J, Anoop Chandran P, Engel J, Hönig A, Ossadnik M, Horn E, Fischer B, Krockenberger M, Heuer S, Seida A, Junker M, Kneitz H, Kloor D, Klotz K, Dietl J, Wischhusen J
Cancer Immunology, Immunotherapy 2011;60(10):1405-1418

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CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

Serra S, Horenstein A, Vaisitti T, Brusa D, Rossi D, Laurenti L, D'Arena G, Coscia M, Tripodo C, Inghirami G, Robson S, Gaidano G, Malavasi F, Deaglio S
Blood 2011;118(23):6141-6152