RA0534

antibody from Oursmab
Targeting: NT5E CALJA, CD73, eN, eNT, NT5
Provider product page for RA0534
Western blot
ELISA
Immunocytochemistry
Flow cytometry
Functional assay

Antibody data

Product number
RA0534 - Provider product page
Provider
Oursmab
Product name
Mupadolimab (Biosimilar Reference Antibody) (NT5E)
Antibody type
Monoclonal
Description
Mupadolimab (also known as CPI-006) is a humanized IgG1-kappa monoclonal antibody targeting CD73 (ecto-5¡ä-nucleotidase), an enzyme that converts extracellular AMP into adenosine¡ªan immunosuppressive metabolite. A key feature of mupadolimab is its Fc¦ÃR-binding-deficient (Fc-silent) design, which minimizes effector functions (e.g., ADCC, CDC) and focuses the mechanism on direct immunomodulation. Rather than simply blocking CD73 enzymatic activity, mupadolimab acts as an agonist of CD73-positive B cells, promoting their activation, maturation, expression of antigen-presentation markers, and secretion of IgM and IgG. It is being developed as an immune-activating therapy for advanced cancers, with the goal of enhancing anti-tumor B-cell and T-cell responses.
Reactivity
Human
Isotype
IgG
Vial size
100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg
Concentration
Bottled at the concentration indicated on the vial.
Storage
Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.
NT5E protein structure - RA0534 shown in red.