Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10889-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10889-1-AP, RRID:AB_2153875
- Product name
- NPTX2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated NPTX2 antibody (Cat. #10889-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NARP-related alterations in the excitatory and inhibitory circuitry of socially isolated mice: developmental insights and implications for autism spectrum disorder.
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.
Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation.
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.
NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL.
Single-cell transcriptomic analysis reveals rich pituitary-Immune interactions under systemic inflammation.
Intrauterine Growth Restriction Disrupts the Postnatal Critical Period of Synaptic Plasticity in the Mouse Dorsal Hippocampus in a Model of Hypertensive Disease of Pregnancy.
Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer.
Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease.
Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2).
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning.
NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6.
NPTX2 is a key component in the regulation of anxiety.
Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers.
The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.
Yamaguchi Y, Okamura K, Yamamuro K, Okumura K, Komori T, Toritsuka M, Takada R, Nishihata Y, Ikawa D, Yamauchi T, Makinodan M, Yoshino H, Saito Y, Matsuzaki H, Kishimoto T, Kimoto S
Frontiers in psychiatry 2024;15:1403476
Frontiers in psychiatry 2024;15:1403476
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD.
Hruska-Plochan M, Wiersma VI, Betz KM, Mallona I, Ronchi S, Maniecka Z, Hock EM, Tantardini E, Laferriere F, Sahadevan S, Hoop V, Delvendahl I, Pérez-Berlanga M, Gatta B, Panatta M, van der Bourg A, Bohaciakova D, Sharma P, De Vos L, Frontzek K, Aguzzi A, Lashley T, Robinson MD, Karayannis T, Mueller M, Hierlemann A, Polymenidou M
Nature 2024 Feb;626(8001):1073-1083
Nature 2024 Feb;626(8001):1073-1083
Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation.
Nugent M, St Pierre M, Brown A, Nassar S, Parmar P, Kitase Y, Duck SA, Pinto C, Jantzie L, Fung C, Chavez-Valdez R
Developmental neuroscience 2023;45(5):234-254
Developmental neuroscience 2023;45(5):234-254
Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.
Chen XQ, Zuo X, Becker A, Head E, Mobley WC
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 May;19(5):2095-2116
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023 May;19(5):2095-2116
Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.
Aryal S, Bonanno K, Song B, Mani DR, Keshishian H, Carr SA, Sheng M, Dejanovic B
Cell reports 2023 May 30;42(5):112497
Cell reports 2023 May 30;42(5):112497
NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL.
Kang T, Zhang C, Lei H, Luo R, Liu M, Wang S, Zhang X, Duan Q, Xiao S, Zheng Y
The Journal of investigative dermatology 2023 Jun;143(6):977-988.e2
The Journal of investigative dermatology 2023 Jun;143(6):977-988.e2
Single-cell transcriptomic analysis reveals rich pituitary-Immune interactions under systemic inflammation.
Yan T, Wang R, Yao J, Luo M
PLoS biology 2023 Dec;21(12):e3002403
PLoS biology 2023 Dec;21(12):e3002403
Intrauterine Growth Restriction Disrupts the Postnatal Critical Period of Synaptic Plasticity in the Mouse Dorsal Hippocampus in a Model of Hypertensive Disease of Pregnancy.
St Pierre M, Rastogi N, Brown A, Parmar P, Lechner C, Fung C, Chavez-Valdez R
Developmental neuroscience 2022;44(4-5):214-232
Developmental neuroscience 2022;44(4-5):214-232
Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer.
Su Y, Huang Q, Lu L, Qu H, Wang D, Qiu J, Li W, Lin M, Liu H, Wang Z, Yang X
Journal of Cancer 2022;13(2):706-714
Journal of Cancer 2022;13(2):706-714
Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease.
Sathe G, Albert M, Darrow J, Saito A, Troncoso J, Pandey A, Moghekar A
Journal of neurochemistry 2021 Mar;156(6):988-1002
Journal of neurochemistry 2021 Mar;156(6):988-1002
Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2).
Pei L, Lv X, Jia G, Tan X, Li M, Zhang A
Bioengineered 2021 Dec;12(1):8279-8295
Bioengineered 2021 Dec;12(1):8279-8295
Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.
Kovács RÁ, Vadászi H, Bulyáki É, Török G, Tóth V, Mátyás D, Kun J, Hunyadi-Gulyás É, Fedor FZ, Csincsi Á, Medzihradszky K, Homolya L, Juhász G, Kékesi KA, Józsi M, Györffy BA, Kardos J
Frontiers in immunology 2020;11:599771
Frontiers in immunology 2020;11:599771
Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning.
Cai M, Zhu Y, Li Z, Josephs-Spaulding J, Zhou Y, Hu Y, Chen H, Liu Y, He W, Zhang J
Neuroscience 2019 May 15;406:249-261
Neuroscience 2019 May 15;406:249-261
NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6.
Xu C, Tian G, Jiang C, Xue H, Kuerbanjiang M, Sun L, Gu L, Zhou H, Liu Y, Zhang Z, Xu Q
Cell death & disease 2019 Mar 4;10(3):217
Cell death & disease 2019 Mar 4;10(3):217
NPTX2 is a key component in the regulation of anxiety.
Chang S, Bok P, Tsai CY, Sun CP, Liu H, Deussing JM, Huang GJ
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2018 Aug;43(9):1943-1953
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2018 Aug;43(9):1943-1953
Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers.
Zhang L, Gao J, Li Z, Gong Y
Digestive diseases and sciences 2012 Oct;57(10):2608-14
Digestive diseases and sciences 2012 Oct;57(10):2608-14
The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.
Zhang L, Gao J, Li L, Li Z, Du Y, Gong Y
Molecular biology reports 2011 Nov;38(8):4903-11
Molecular biology reports 2011 Nov;38(8):4903-11
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 10889-1-AP(NPTX2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The NPTX2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human NPTX2. This antibody recognizes human, mouse, rat antigen. The NPTX2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
