BS7770

antibody from Bioworld Technology, Inc

Targeting: LGI1 EPITEMPIN, EPT, ETL1, IB1099

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS7770

Provider

Bioworld Technology, Inc

Product name

LGI1 polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human LGI1.

Description

As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN (also designated MMAC1 and TEP1), DMBT1 (for deleted in malignant brain tumors 1) and LGI1 (for leucine-rich gene-glioma inactivated 1) candidate tumor suppressor genes. The PTEN gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. Reduced levels of DMBT1 mRNA have been noted in gastrointestinal and esophageal cancers as well as in gliomas. LGI1, which is highly specific for neural tissues, shares homology with several transmembrane and extracellular proteins that function as receptors and adhesion proteins.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.