ENTPD7

This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017]

Description

Ectonucleoside triphosphate diphosphohydrolase 7

Tissue specificity

Tissue enhanced (intestine)

Subcell location

Nucleoplasm

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

10 (99659509 - 99711241)

Ensembl ID

ENSG00000198018  (ver. 103.38)

Orthologs

Mouse Entpd7: ENSMUSG00000025192

UniProt

Q9NQZ7

neXtProt

NX_Q9NQZ7

Human splice variants
Mouse splice variants

Protein structure