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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 316917 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#316917, RRID:AB_2565590
- Product name
- PerCP/Cy5.5 anti-human CD268 (BAFF-R)
- Antibody type
- Monoclonal
- Antigen
- BAFF-R-L1.2 transfectants
- Description
- B cell-activating factor receptor (BAFF-R) is a 19 kD type III membrane protein. It belongs to TNFR superfamily, also known as TNFRSF member 13C (TNFRSF13C), BAFF receptor 3 (BR3), or CD268. BAFF-R is expressed on mature B cells, B cell lymphoma, and T cell subset. BAFF-R is the major receptor for BAFF/BLys (or TALL-1, THANK) which binds to TACI and BCMA as well. The interaction of BAFF with BAFF-R promotes NF-κB activation and plays predominant roles in B-cell maturation and survival as well as costimulates T cell activation and proliferation. TRAF3 is a BAFF-R intracellularly associated protein, which negatively regulates BAFF-R-mediated NF-κB activation.
- Reactivity
- Human
- Host
- Mouse
- Antibody clone number
- 11C1
- Vial size
- 25 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood lymphocytes were stained with CD19 APC and CD268 (clone 11C1) PerCp/Cy5.5 (top) or mouse IgG1, κ PerCp/Cy5.5 isotype control (bottom).
