TNFRSF13C

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Description

TNF receptor superfamily member 13C

Tissue specificity

Group enriched (intestine, lymphoid tissue)

Predicted location

Membrane

Protein family

CD markers
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

22 (41922032 - 41926806)

Ensembl ID

ENSG00000159958  (ver. 103.38)

Orthologs

Mouse Tnfrsf13c: ENSMUSG00000068105

UniProt

Q96RJ3

neXtProt

NX_Q96RJ3

Human splice variants
Mouse splice variants

Protein structure