SEMA3F

This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Description

Semaphorin 3F

Tissue specificity

Tissue enhanced (esophagus)

Predicted location

Intracellular, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (50155045 - 50189075)

Ensembl ID

ENSG00000001617  (ver. 103.38)

Orthologs

Mouse Sema3f: ENSMUSG00000034684

UniProt

Q13275

neXtProt

NX_Q13275

Human splice variants
Mouse splice variants

Protein structure