orb1824534

antibody from Biorbyt

Targeting: PTPRU FMI, hPTP-J, PCP-2, PTP, PTPRO

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb1824534

Provider

Biorbyt

Product name

PTPRU Antibody / Protein Tyrosine Phosphatase Receptor Type U

Antibody type

Monoclonal

Description

Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTPa, PTPb, PTPg, PTPd, PTPe, PTPz, PTPk, PTPm and PTPy. Transmembrane PTPs play diverse roles in a variety of cellular processes during development and in adult tissues. PTPy, also known as PTPRU, FMI, PCP-2, PTP-J, PTPRO, PTP-PI, PTPPSI or GLEPP1, is a receptor-type PTP containing a transmembrane region, two intracellular tandem catalytic domains, and an extracellular region with Ig-like and fibronectin type III-like repeats and a MAM (meprin-A5 antigen-PTPm) domain. PTPy localizes to adheren junctions and is capable of binding and dephosphorylating b-catenin thereby functioning as a negative regulator of b-catenin signaling. In addition, PTPy may function as a tumor suppressor, as its expression is silenced in a variety of tumors via methylation of its promoter.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

PTPRU/7616

Vial size

20 ug

Storage

Aliquot the PTPRU antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.