RASA4

This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

RAS p21 protein activator 4

Tissue specificity

Group enriched (skeletal muscle, tongue)

Subcell location

Vesicles, Cell Junctions

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Chromosome

7 (102573807 - 102616756)

Ensembl ID

ENSG00000105808  (ver. 103.38)

Orthologs

-

UniProt

O43374

neXtProt

NX_O43374

Human splice variants

Protein structure