KCNN4

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Description

Potassium calcium-activated channel subfamily N member 4

Tissue specificity

Tissue enhanced (salivary gland)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

19:q13.31 (43766533 - 43781257)

Ensembl ID

ENSG00000104783  (ver. 103.38)

Orthologs

Mouse Kcnn4: ENSMUSG00000054342

UniProt

O15554

neXtProt

NX_O15554

Human splice variants
Mouse splice variants