Antibody data
- Antibody Data
- Antigen structure
- References [25]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 15310-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15310-1-AP, RRID:AB_2224185
- Product name
- ALDH2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ALDH2 antibody (Cat. #15310-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.
Daily Dose of Bovine Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota.
Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.
Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition.
Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.
Combination of podophyllotoxin and rutin modulate radiation-induced alterations of jejunal proteome in mice.
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Aldehyde dehydrogenase 2 protects against sympathetic excitation-induced cardiac fibrosis.
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice.
A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines.
Limitations of lymphoblastoid cell lines for functional analysis of SNPs.
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.
Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.
Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.
Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque.
Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.
Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium.
Maternal aldehyde elimination during pregnancy preserves the fetal genome.
Ji W, Wan T, Zhang F, Zhu X, Guo S, Mei X
Frontiers in pharmacology 2021;12:641058
Frontiers in pharmacology 2021;12:641058
Daily Dose of Bovine Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota.
Li D, He Q, Yang H, Du Y, Yu K, Yang J, Tong X, Guo Y, Xu J, Qin L
Molecular nutrition & food research 2021 Sep;65(18):e2100253
Molecular nutrition & food research 2021 Sep;65(18):e2100253
Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.
Chao X, Wang S, Yang L, Ni HM, Ding WX
Alcoholism, clinical and experimental research 2021 Oct;45(10):1950-1964
Alcoholism, clinical and experimental research 2021 Oct;45(10):1950-1964
Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition.
Foucault A, Ravalet N, Besombes J, Picou F, Gallay N, Babin L, Bourgeais J, Hamard S, Domenech J, Loyer P, Vallet N, Lejeune J, Gyan E, Béné MC, Vallette F, Olivier C, Hérault O
Cancers 2021 Nov 14;13(22)
Cancers 2021 Nov 14;13(22)
Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.
Zhang H, Xia Y, Wang F, Luo M, Yang K, Liang S, An S, Wu S, Yang C, Chen D, Xu M, Cai M, To KKW, Fu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(10):2003404
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(10):2003404
Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.
Zhong S, Li L, Liang N, Zhang L, Xu X, Chen S, Yin H
Redox biology 2021 May;41:101919
Redox biology 2021 May;41:101919
Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.
Mu A, Hira A, Niwa A, Osawa M, Yoshida K, Mori M, Okamoto Y, Inoue K, Kondo K, Kanemaki MT, Matsuda T, Ito E, Kojima S, Nakahata T, Ogawa S, Tanaka K, Matsuo K, Saito MK, Takata M
Blood 2021 Apr 15;137(15):2021-2032
Blood 2021 Apr 15;137(15):2021-2032
Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.
Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385
Molecular medicine reports 2020 Sep;22(3):2373-2385
Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.
Liu YC, Wang HL, Huang YZ, Weng YH, Chen RS, Tsai WC, Yeh TH, Lu CS, Chen YL, Lin YW, Chen YJ, Hsu CC, Chiu CH, Chiu CC
Biochemical pharmacology 2020 May;175:113919
Biochemical pharmacology 2020 May;175:113919
Combination of podophyllotoxin and rutin modulate radiation-induced alterations of jejunal proteome in mice.
Bajaj S, Alam SI, Ahmad B, Farooqi H, Gupta ML
International journal of radiation biology 2020 Jul;96(7):879-893
International journal of radiation biology 2020 Jul;96(7):879-893
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA, Wang M, Mu A, Millington CL, Oberbeck N, Watcham S, Pontel LB, Kamimae-Lanning AN, Langevin F, Nadler C, Cordell RL, Monks PS, Yu R, Wilson NK, Hira A, Yoshida K, Mori M, Okamoto Y, Okuno Y, Muramatsu H, Shiraishi Y, Kobayashi M, Moriguchi T, Osumi T, Kato M, Miyano S, Ito E, Kojima S, Yabe H, Yabe M, Matsuo K, Ogawa S, Göttgens B, Hodskinson MRG, Takata M, Patel KJ
Molecular cell 2020 Dec 17;80(6):996-1012.e9
Molecular cell 2020 Dec 17;80(6):996-1012.e9
Aldehyde dehydrogenase 2 protects against sympathetic excitation-induced cardiac fibrosis.
Yuan Q, Yang F, Dai S, Wang Z, Xu Y, Xu BC, Sun Y, Zheng B, Zhao Y, Wang W, Liu B, Wang J, Cui S, Cao S, Zhang R, Xue L, Wei S, Xue M, Xu T, Xu F, Chen Y
Biochemical and biophysical research communications 2020 Dec 17;533(4):1427-1434
Biochemical and biophysical research communications 2020 Dec 17;533(4):1427-1434
Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.
Wakabayashi Y, Tamura Y, Kouzaki K, Kikuchi N, Hiranuma K, Menuki K, Tajima T, Yamanaka Y, Sakai A, Nakayama KI, Kawamoto T, Kitagawa K, Nakazato K
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Apr 1;318(4):R677-R690
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Apr 1;318(4):R677-R690
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
The Journal of clinical investigation 2019 Jan 2;129(1):252-267
Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice.
Li M, Xu M, Li J, Chen L, Xu D, Tong Y, Zhang J, Wu H, Kong X, Xia Q
Journal of immunology research 2018;2018:9807139
Journal of immunology research 2018;2018:9807139
A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines.
Wang F, Guo T, Jiang H, Li R, Wang T, Zeng N, Dong G, Zeng X, Li D, Xiao Y, Hu Q, Chen W, Xing X, Wang Q
Molecular genetics and genomics : MGG 2018 Jun;293(3):769-783
Molecular genetics and genomics : MGG 2018 Jun;293(3):769-783
Limitations of lymphoblastoid cell lines for functional analysis of SNPs.
Pathak H, Frieling H, Rhein M, Burkert A
BMC research notes 2017 Nov 2;10(1):548
BMC research notes 2017 Nov 2;10(1):548
Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.
Liu G, Park SH, Imbesi M, Nathan WJ, Zou X, Zhu Y, Jiang H, Parisiadou L, Gius D
Antioxidants & redox signaling 2017 May 20;26(15):849-863
Antioxidants & redox signaling 2017 May 20;26(15):849-863
Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.
Bae S, Chon J, Field MS, Stover PJ
The Journal of nutrition 2017 Apr;147(4):499-505
The Journal of nutrition 2017 Apr;147(4):499-505
Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.
Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR
PloS one 2016;11(4):e0154152
PloS one 2016;11(4):e0154152
Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.
Liu H, Zhang H, Cui R, Guo X, Wang D, Dai J
Archives of toxicology 2016 Jun;90(6):1383-97
Archives of toxicology 2016 Jun;90(6):1383-97
Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque.
Pan C, Xing JH, Zhang C, Zhang YM, Zhang LT, Wei SJ, Zhang MX, Wang XP, Yuan QH, Xue L, Wang JL, Cui ZQ, Zhang Y, Xu F, Chen YG
Oncotarget 2016 Jun 14;7(24):35562-35576
Oncotarget 2016 Jun 14;7(24):35562-35576
Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.
Ying Q, Ansong E, Diamond AM, Lu Z, Yang W, Bie X
PloS one 2015;10(5):e0126285
PloS one 2015;10(5):e0126285
Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium.
Amanuma Y, Ohashi S, Itatani Y, Tsurumaki M, Matsuda S, Kikuchi O, Nakai Y, Miyamoto S, Oyama T, Kawamoto T, Whelan KA, Nakagawa H, Chiba T, Matsuda T, Muto M
Scientific reports 2015 Sep 16;5:14142
Scientific reports 2015 Sep 16;5:14142
Maternal aldehyde elimination during pregnancy preserves the fetal genome.
Oberbeck N, Langevin F, King G, de Wind N, Crossan GP, Patel KJ
Molecular cell 2014 Sep 18;55(6):807-817
Molecular cell 2014 Sep 18;55(6):807-817
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse lung tissue were subjected to SDS PAGE followed by western blot with 15310-1-AP(ALDH2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 15310-1-AP(ALDH2 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ALDH2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ALDH2. This antibody recognizes human,mouse,rat antigen. The ALDH2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.