15310-1-AP

antibody from Proteintech Group

Targeting: ALDH2

Provider product page for 15310-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [82]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 15310-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15310-1-AP, RRID:AB_2224185
Product name: ALDH2 antibody
Antibody type: Polyclonal
Description: KD/KO validated ALDH2 antibody (Cat. #15310-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ALDH2 protein structure - 15310-1-AP shown in red.

Submitted references Global lactylation is downregulated despite lactate accumulation: lactylome data and functional insights during ISKNV infection.

Sun Z, Niu Y, Fu X, Lin Q, Cao X, Liang H, Luo X, Ma B, Xiao W, Li N, Chen J
Fish & shellfish immunology 2026 Jul;174:111345

ALDH2 deficiency aggravates vascular injury-induced restenosis by enhancing vascular smooth muscle cell proliferation through SLC38A2-mediated upregulation of glutamine uptake.

Hou D, Yang K, Liu Y, Du H, Yue H, Xu F, Sang W, Zhao X, Sun Y, Xu F, Chen Y
Metabolism: clinical and experimental 2026 Jan;174:156411

ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury.

Chen X, Yu X, Zhong S, Sha P, Li R, Xu X, Liang N, Zhang L, Li L, Zhang J, Zhou M, Lv T, Ma H, Wang Y, Ye Y, Yin C, Chen S, Tian J, Sun A, Wang W, Yan D, Yang HT, Huang H, Li P, Yin H
Circulation 2026 Jan 20;153(3):164-184

Long-term exposure to the ethanol-derived metabolite acetaldehyde elevates structural genomic alterations but not base substitutions.

Lózsa R, Szikriszt B, Németh E, Szeltner Z, Martinek R, Póti Á, Feik T, Kollarics S, Márkus BG, Kanu N, Sztupinszki Z, Simon F, Shibata T, Swanton C, Szallasi Z, Richardson AL, Szüts D
Communications biology 2026 Jan 17;9(1):243

Mitochondrial protein-enriched artificial nanovesicles: mitochondrial recovery and antioxidation for diabetic wound treatment.

Xia J, Wang L, Song Y, Zhu M, Xu Y, Liu J, Guan X, Zhang Q, He K, Wang F, Liu L, Liu J
Journal of nanobiotechnology 2026 Feb 5;24(1)

MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease.

Shu T, Zeng X, Wang J, Jiang H, Wang Y, Zhang M, Jiang L, He B, Yang L, Liu N, Tang M, Jiang Y, Zhang L, Chen P, Xie J, Fang D, Lee KE, Chen Y, Kim J, Liu R, Ye Y, Han Y, Ma J, Zeng C
Nature communications 2026 Feb 13;17(1)

E3 ubiquitin ligase TRIM21-mediated K48-linked ubiquitination of ALDH2 rs671 mutant promotes adverse cardiac remodeling.

Han T, Wen X, Guo Y, Zhao X, Zhang J, Chen Y, Xu F
JCI insight 2026 Apr 8;11(7)

Effect of gentiopicroside on endogenous formaldehyde homocysteine-pathway related proteins in rats with non-alcoholic steatohepatitis.

Chen J, Zuo H, Jiao Y, Zhao H, Ma X, Xiao Y, Li X, Zhao W, Shi A, Chen W
Frontiers in pharmacology 2025;16:1700101

Host ALDH2 deficiency aggravates acetaldehyde metabolism disturbance and gut microbiota dysbiosis in chronic alcohol exposure mice.

Tan X, Wu B, Wen X, Li Y, Xu X
Frontiers in microbiology 2025;16:1617673

Tanshinone I promotes angiogenesis and improves ventricular remodeling post-myocardial infarction via ALDH2 signaling-mediated ferroptosis inhibition.

Zhang F, Li L, Liu Q, Wang WL, Wang ZX, Song RQ, Sun J, Zhang YY, Ren XC, Wang D, Wu YT
Frontiers in pharmacology 2025;16:1601017

Baicalin alleviates pathological changes in Alzheimer's disease comorbid with type 2 diabetes: Targeting metabolic dysregulation and neuroinflammation.

Song ZY, Yu WJ, Jin YJ, Zhou MF, He CX, Li Z, He JW, Chen Q, Li P, Yi Y, Cheng SW
Journal of ethnopharmacology 2025 Sep 25;353(Pt A):120352

Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.

Godoy-Lugo JA, Hicks D, Durra S, Massey ER, Shkirkova K, Sauri AI, Kerstiens E, Chen S, Zhao L, Sioutas C, Mack WJ, Finch CE, Thorwald MA
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845

Nano-Self-Assembled Particles Loaded with Aldehyde Dehydrogenase 2 Agonist Inhibit Ischemia-Reperfusion Injury of Transplanted Kidneys.

Hu Q, Lu Z, Yasen K, Liu A, Shi X, Ye Q, Zhong Z
ACS nano 2025 Oct 14;19(40):35853-35870

Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in Aldh2∗2 knock-in mice.

Takami Y, Nakamura J, Katahira J, Maeda Y, Tanaka M, Kuwamura M, Okada T, Izawa T
Free radical biology & medicine 2025 Nov;239:177-188

ALDH2 inhibits angiogenesis in esophageal squamous cell carcinoma by suppressing the NOTCH1/PI3K/Akt signaling pathway.

Qiang J, Qiu T, Yang Y, Xu B, Huang H, Li X, Ma R, Lu Y, Dong Z
Cellular signalling 2025 Nov;135:112025

Heavy alcohol use exacerbates skeletal myopathy in peripheral artery disease.

Koutakis P, Fletcher E, Papoutsi E, Bohannon WT, Pipinos II, Miserlis D, Pacher P
GeroScience 2025 Nov 12;

Aldehyde dehydrogenase 2 attenuates renal injury through inhibiting CYP4A expression.

Chen H, Hu Q, Lu Z, Zhao J, Liu A, Liu Z, Luo J, Ye Q, Zhong Z
Translational research : the journal of laboratory and clinical medicine 2025 Mar;277:1-12

Multi-Omics Profiling Reveals Glycerolipid Metabolism-Associated Molecular Subtypes and Identifies ALDH2 as a Prognostic Biomarker in Pancreatic Cancer.

Liu J, Ma S, Deng D, Yang Y, Li J, Zhang Y, Yin P, Shang D
Metabolites 2025 Mar 18;15(3)

Aldehydic load as an objective imaging biomarker of mild traumatic brain injury.

Kirby A, Ward C, Goulet CS, Calvert ND, Daniel R, Leung JW, Sharma A, Suchý M, Donatelli C, Wang J, Standen E, Shuhendler AJ
Npj imaging 2025 Jun 26;3(1):30

Hydrogen peroxide-induced oxidative stress alters protein expression in two rat salivary acinar cell lines.

Golnarnik G, Thiede B, Søland TM, Galtung HK, Haug TM
Archives of oral biology 2025 Jul;175:106254

Gualou Xiebai Banxia Decoction suppresses cardiomyocyte apoptosis in mice after myocardial infarction through activation of acetaldehyde dehydrogenase 2.

Deng B, Zhang G, Zeng Y, Li N, Hu C, Pang M, Lu S, Gu Y, Chen G, Zhou Y, Liu Y, Hua Y
Journal of ethnopharmacology 2025 Jan 13;339:119143

ALDH2 protects against dopaminergic neuronal cell ferroptosis by enhancing the enzyme activity of PRDX6 in Parkinson's disease.

Li X, Peng SJ, Wang Y, Chen X, Wu TT, Feng Y, Wang XX, Yin H, Wu YC
NPJ Parkinson's disease 2025 Dec 2;11(1):350

The ALDH2/PolG2 axis enhances mitochondrial biogenesis via transcriptional regulation of Nrf2 and promotes chemotherapy resistance in acute myeloid leukaemia.

Hu X, Hu T, Cao S, Jiang L, Zhou Y, Fang Q, Wang J
Cell death & disease 2025 Aug 13;16(1):616

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.

Sugimoto A, Saito Y, Wang G, Sun Q, Yin C, Lee KH, Geng Y, Rajbhandari P, Hernandez C, Steffani M, Qie J, Savage T, Goyal DM, Ray KC, Neelakantan TV, Yin D, Melms J, Lehrich BM, Yasaka TM, Liu S, Oertel M, Lan T, Guillot A, Peiseler M, Filliol A, Kanzaki H, Fujiwara N, Ravi S, Izar B, Brosch M, Hampe J, Remotti H, Argemi J, Sun Z, Kendall TJ, Hoshida Y, Tacke F, Fallowfield JA, Blockley-Powell SK, Haeusler RA, Steinman JB, Pajvani UB, Monga SP, Bataller R, Masoodi M, Arpaia N, Lee YA, Stockwell BR, Augustin HG, Schwabe RF
Nature 2025 Apr;640(8059):752-761

Alda-1 mediates cell senescence and counteracts bone loss in weightlessness through regulating mitophagy.

Wang J, Li S, Li Q, Yan Q, Wang Y, Zeng X, Yang F, Jiang S, Zhang M, Pi Y, Tahir R, Wei L
Life sciences 2025 Apr 1;366-367:123482

Identification and Validation of a Necroptosis-Related Prognostic Model in Tumor Recurrence and Tumor Immune Microenvironment in Breast Cancer Management.

Wang X, Chen Z, Tang J, Cao J
Journal of inflammation research 2024;17:5057-5076

Aldehydes alter TGF-β signaling and induce obesity and cancer.

Yang X, Bhowmick K, Rao S, Xiang X, Ohshiro K, Amdur RL, Hassan MI, Mohammad T, Crandall K, Cifani P, Shetty K, Lyons SK, Merrill JR, Vegesna AK, John S, Latham PS, Crawford JM, Mishra B, Dasarathy S, Wang XW, Yu H, Wang Z, Huang H, Krainer AR, Mishra L
Cell reports 2024 Sep 24;43(9):114676

Sirtuin 5-Mediated Desuccinylation of ALDH2 Alleviates Mitochondrial Oxidative Stress Following Acetaminophen-Induced Acute Liver Injury.

Yu Q, Zhang J, Li J, Song Y, Pan J, Mei C, Cui M, He Q, Wang H, Li H, Cheng B, Zhang Y, Guo W, Zhu C, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2402710

Targeting Retinaldehyde Dehydrogenases to Enhance Temozolomide Therapy in Glioblastoma.

Jiménez R, Constantinescu A, Yazir M, Alfonso-Triguero P, Pequerul R, Parés X, Pérez-Alea M, Candiota AP, Farrés J, Lorenzo J
International journal of molecular sciences 2024 Oct 26;25(21)

Myocardial reperfusion injury exacerbation due to ALDH2 deficiency is mediated by neutrophil extracellular traps and prevented by leukotriene C4 inhibition.

Yang K, Gao R, Chen H, Hu J, Zhang P, Wei X, Shi J, Chen Y, Zhang L, Chen J, Lyu Y, Dong Z, Wei W, Hu K, Guo Y, Ge J, Sun A
European heart journal 2024 May 13;45(18):1662-1680

The aldehyde dehydrogenase 2 rs671 variant enhances amyloid β pathology.

Wang X, Wang J, Chen Y, Qian X, Luo S, Wang X, Ma C, Ge W
Nature communications 2024 Mar 22;15(1):2594

Effects of Hovenia dulcis fruit and peduncle extract on alcohol metabolism.

Niiya M, Shimato Y, Ohno T, Makino T
Journal of ethnopharmacology 2024 Mar 1;321:117541

Icariin attenuates asthmatic airway inflammation via modulating alveolar macrophage activation based on network pharmacology and in vivo experiments.

Zhu X, Wang B, Yu H, Li C, Zhao Y, Zhong Y, Tang W, Zhou Y, Huang X, Zhu H, Wu Y, Yang K, Wei Y, Gao Z, Dong J
The journal of gene medicine 2024 Jul;26(7):e3718

Mitochondrial aldehyde dehydrogenase-2 coordinates the hydrogen sulfide - AMPK axis to attenuate high glucose-induced pancreatic β-cell dysfunction by glutathione antioxidant system.

Karunakaran U, Elumalai S, Chung SM, Maedler K, Won KC, Moon JS
Redox biology 2024 Feb;69:102994

ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.

Luo J, Lu Z, Zhong Z, Pi M, Xiong Y, Li L, Chen T, Chen Y, Wang CY, Liu Z, Ye Q
Free radical biology & medicine 2024 Feb 20;212:34-48

Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.

Wei Y, Gao S, Li C, Huang X, Xie B, Geng J, Dai H, Wang C
The American journal of pathology 2024 Aug;194(8):1458-1477

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.

Liu J, Duangjan C, Irwin RW, Curran SP
Mechanisms of ageing and development 2024 Apr;218:111914

DNMT1 mediates the disturbed flow-induced endothelial to mesenchymal transition through disrupting β-alanine and carnosine homeostasis.

Zhao J, Zhao C, Yang F, Jiang Z, Zhu J, Yao W, Pang W, Zhou J
Theranostics 2023;13(13):4392-4411

Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.

Zhou H, Wan S, Luo Y, Liu H, Jiang J, Guo Y, Xiao J, Wu B
Gastroenterology report 2023;11:goad006

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.

Liu J, Duangjan C, Irwin RW, Curran SP
bioRxiv : the preprint server for biology 2023 Oct 11;

The Binding of HSPA8 and Mitochondrial ALDH2 Mediates Oxygen-Glucose Deprivation-Induced Fibroblast Senescence.

Hui W, Song T, Yu L, Chen X
Antioxidants (Basel, Switzerland) 2023 Dec 25;13(1)

p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.

Yao P, Zhang Z, Liu H, Jiang P, Li W, Du W
The EMBO journal 2023 Apr 17;42(8):e112304

The Effects of Alda-1 Treatment on Renal and Intestinal Injuries After Cardiopulmonary Resuscitation in Pigs.

Yu Q, Gao J, Shao X, Lu W, Chen L, Jin L
Frontiers in medicine 2022;9:892472

SIRT3 inhibitor 3-TYP exacerbates thioacetamide-induced hepatic injury in mice.

Shi C, Jiao F, Wang Y, Chen Q, Wang L, Gong Z
Frontiers in physiology 2022;13:915193

High ALDH2 expression is associated with better prognosis in patients with gastric cancer.

Yao S, Gan C, Wang T, Zhang Q, Zhang M, Cheng H
American journal of cancer research 2022;12(12):5425-5439

Impact and potential mechanism of effects of chronic moderate alcohol consumption on cardiac function in aldehyde dehydrogenase 2 gene heterozygous mice.

Hu Q, Chen H, Shen C, Zhang B, Weng X, Sun X, Liu J, Dong Z, Hu K, Ge J, Sun A
Alcoholism, clinical and experimental research 2022 May;46(5):707-723

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells.

Brunsdon H, Brombin A, Peterson S, Postlethwait JH, Patton EE
Development (Cambridge, England) 2022 May 15;149(10)

Metabolomics of oxidative stress: Nrf2 independent depletion of NAD or increases of sugar alcohols.

Zhu C, Gu H, Jin Y, Wurm D, Freidhof B, Lu Y, Chen QM
Toxicology and applied pharmacology 2022 May 1;442:115949

Baicalin ameliorates alcohol-induced hepatic steatosis by suppressing SREBP1c elicited PNPLA3 competitive binding to ATGL.

Li P, Chen Y, Ke X, Zhang R, Zuo L, Wang M, Chen Z, Luo X, Wang J
Archives of biochemistry and biophysics 2022 Jun 15;722:109236

Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.

Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Jun 1;322(6):R511-R525

Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.

Li DM, Wu YX, Hu ZQ, Wang TC, Zhang LL, Zhou Y, Tong X, Xu JY, Qin LQ
Antioxidants (Basel, Switzerland) 2022 Jul 31;11(8)

Effect of different types of muscle activity on the gene and protein expression of ALDH family members in C57BL/6J mouse skeletal muscle.

Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2022 Jul 1;47(7):775-786

The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models.

Wu J, Miyasaka K, Yamada W, Takeda S, Shimizu N, Shimoda H
Molecules (Basel, Switzerland) 2022 Jan 18;27(3)

Alda-1, an Activator of ALDH2, Improves Postresuscitation Cardiac and Neurological Outcomes by Inhibiting Pyroptosis in Swine.

Diao M, Xu J, Wang J, Zhang M, Wu C, Hu X, Zhu Y, Zhang M, Hu W
Neurochemical research 2022 Apr;47(4):1097-1109

Aldehyde dehydrogenase 2 and PARP1 interaction modulates hepatic HDL biogenesis by LXRα-mediated ABCA1 expression.

Li L, Zhong S, Li R, Liang N, Zhang L, Xia S, Xu X, Chen X, Chen S, Tao Y, Yin H
JCI insight 2022 Apr 8;7(7)

Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.

Ji W, Wan T, Zhang F, Zhu X, Guo S, Mei X
Frontiers in pharmacology 2021;12:641058

ALDH2 is a prognostic biomarker and related with immune infiltrates in HCC.

Yao S, Yin X, Chen T, Chen W, Zuo H, Bi Z, Zhang X, Jing Y, Pang L, Cheng H
American journal of cancer research 2021;11(11):5319-5337

Daily Dose of Bovine Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota.

Li D, He Q, Yang H, Du Y, Yu K, Yang J, Tong X, Guo Y, Xu J, Qin L
Molecular nutrition & food research 2021 Sep;65(18):e2100253

Transcriptional Silencing of ALDH2 Confers a Dependency on Fanconi Anemia Proteins in Acute Myeloid Leukemia.

Yang Z, Wu XS, Wei Y, Polyanskaya SA, Iyer SV, Jung M, Lach FP, Adelman ER, Klingbeil O, Milazzo JP, Kramer M, Demerdash OE, Chang K, Goodwin S, Hodges E, McCombie WR, Figueroa ME, Smogorzewska A, Vakoc CR
Cancer discovery 2021 Sep;11(9):2300-2315

Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice.

Chao X, Wang S, Yang L, Ni HM, Ding WX
Alcoholism, clinical and experimental research 2021 Oct;45(10):1950-1964

Low-Dose Pesticides Alter Primary Human Bone Marrow Mesenchymal Stem/Stromal Cells through ALDH2 Inhibition.

Foucault A, Ravalet N, Besombes J, Picou F, Gallay N, Babin L, Bourgeais J, Hamard S, Domenech J, Loyer P, Vallet N, Lejeune J, Gyan E, Béné MC, Vallette F, Olivier C, Hérault O
Cancers 2021 Nov 14;13(22)

Aldehyde Dehydrogenase 2 Mediates Alcohol-Induced Colorectal Cancer Immune Escape through Stabilizing PD-L1 Expression.

Zhang H, Xia Y, Wang F, Luo M, Yang K, Liang S, An S, Wu S, Yang C, Chen D, Xu M, Cai M, To KKW, Fu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 May;8(10):2003404

Acetaldehyde Dehydrogenase 2 regulates HMG-CoA reductase stability and cholesterol synthesis in the liver.

Zhong S, Li L, Liang N, Zhang L, Xu X, Chen S, Yin H
Redox biology 2021 May;41:101919

Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.

Mu A, Hira A, Niwa A, Osawa M, Yoshida K, Mori M, Okamoto Y, Inoue K, Kondo K, Kanemaki MT, Matsuda T, Ito E, Kojima S, Nakahata T, Ogawa S, Tanaka K, Matsuo K, Saito MK, Takata M
Blood 2021 Apr 15;137(15):2021-2032

Pretreatment with the ALDH2 activator Alda‑1 protects rat livers from ischemia/reperfusion injury by inducing autophagy.

Liu Z, Ye S, Zhong X, Wang W, Lai CH, Yang W, Yue P, Luo J, Huang X, Zhong Z, Xiong Y, Fan X, Li L, Wang Y, Ye Q
Molecular medicine reports 2020 Sep;22(3):2373-2385

Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.

Liu YC, Wang HL, Huang YZ, Weng YH, Chen RS, Tsai WC, Yeh TH, Lu CS, Chen YL, Lin YW, Chen YJ, Hsu CC, Chiu CH, Chiu CC
Biochemical pharmacology 2020 May;175:113919

Combination of podophyllotoxin and rutin modulate radiation-induced alterations of jejunal proteome in mice.

Bajaj S, Alam SI, Ahmad B, Farooqi H, Gupta ML
International journal of radiation biology 2020 Jul;96(7):879-893

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Dingler FA, Wang M, Mu A, Millington CL, Oberbeck N, Watcham S, Pontel LB, Kamimae-Lanning AN, Langevin F, Nadler C, Cordell RL, Monks PS, Yu R, Wilson NK, Hira A, Yoshida K, Mori M, Okamoto Y, Okuno Y, Muramatsu H, Shiraishi Y, Kobayashi M, Moriguchi T, Osumi T, Kato M, Miyano S, Ito E, Kojima S, Yabe H, Yabe M, Matsuo K, Ogawa S, Göttgens B, Hodskinson MRG, Takata M, Patel KJ
Molecular cell 2020 Dec 17;80(6):996-1012.e9

Aldehyde dehydrogenase 2 protects against sympathetic excitation-induced cardiac fibrosis.

Yuan Q, Yang F, Dai S, Wang Z, Xu Y, Xu BC, Sun Y, Zheng B, Zhao Y, Wang W, Liu B, Wang J, Cui S, Cao S, Zhang R, Xue L, Wei S, Xue M, Xu T, Xu F, Chen Y
Biochemical and biophysical research communications 2020 Dec 17;533(4):1427-1434

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.

Wakabayashi Y, Tamura Y, Kouzaki K, Kikuchi N, Hiranuma K, Menuki K, Tajima T, Yamanaka Y, Sakai A, Nakayama KI, Kawamoto T, Kitagawa K, Nakazato K
American journal of physiology. Regulatory, integrative and comparative physiology 2020 Apr 1;318(4):R677-R690

Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.

Zhong S, Li L, Zhang YL, Zhang L, Lu J, Guo S, Liang N, Ge J, Zhu M, Tao Y, Wu YC, Yin H
The Journal of clinical investigation 2019 Jan 2;129(1):252-267

Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice.

Li M, Xu M, Li J, Chen L, Xu D, Tong Y, Zhang J, Wu H, Kong X, Xia Q
Journal of immunology research 2018;2018:9807139

A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines.

Wang F, Guo T, Jiang H, Li R, Wang T, Zeng N, Dong G, Zeng X, Li D, Xiao Y, Hu Q, Chen W, Xing X, Wang Q
Molecular genetics and genomics : MGG 2018 Jun;293(3):769-783

Limitations of lymphoblastoid cell lines for functional analysis of SNPs.

Pathak H, Frieling H, Rhein M, Burkert A
BMC research notes 2017 Nov 2;10(1):548

Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy.

Liu G, Park SH, Imbesi M, Nathan WJ, Zou X, Zhu Y, Jiang H, Parisiadou L, Gius D
Antioxidants & redox signaling 2017 May 20;26(15):849-863

Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.

Bae S, Chon J, Field MS, Stover PJ
The Journal of nutrition 2017 Apr;147(4):499-505

Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage.

Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR
PloS one 2016;11(4):e0154152

Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.

Liu H, Zhang H, Cui R, Guo X, Wang D, Dai J
Archives of toxicology 2016 Jun;90(6):1383-97

Aldehyde dehydrogenase 2 inhibits inflammatory response and regulates atherosclerotic plaque.

Pan C, Xing JH, Zhang C, Zhang YM, Zhang LT, Wei SJ, Zhang MX, Wang XP, Yuan QH, Xue L, Wang JL, Cui ZQ, Zhang Y, Xu F, Chen YG
Oncotarget 2016 Jun 14;7(24):35562-35576

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

Ying Q, Ansong E, Diamond AM, Lu Z, Yang W, Bie X
PloS one 2015;10(5):e0126285

Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium.

Amanuma Y, Ohashi S, Itatani Y, Tsurumaki M, Matsuda S, Kikuchi O, Nakai Y, Miyamoto S, Oyama T, Kawamoto T, Whelan KA, Nakagawa H, Chiba T, Matsuda T, Muto M
Scientific reports 2015 Sep 16;5:14142

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

Oberbeck N, Langevin F, King G, de Wind N, Crossan GP, Patel KJ
Molecular cell 2014 Sep 18;55(6):807-817

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse lung tissue were subjected to SDS PAGE followed by western blot with 15310-1-AP(ALDH2 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver using 15310-1-AP(ALDH2 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ALDH2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ALDH2. This antibody recognizes human,mouse,rat antigen. The ALDH2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 15310-1-AP.pdf

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