ALDH2

gene product
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2016]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
625 antibodies from 35 providers.

Antibody properties

General

Applications

or Cancel
Antibody
antibodies-online
210 antibodies
GeneTex
9 antibodies
Novus Biologicals
43 antibodies
Biorbyt
39 antibodies
Abnova Corporation
10 antibodies
OriGene
10 antibodies
Abgent
11 antibodies
Arigo
4 antibodies
NSJ Bioreagents
5 antibodies
LifeSpan BioSciences, Inc.
99 antibodies
Invitrogen Antibodies
7 antibodies
NovoPro Bioscience Inc.
13 antibodies
Affinity Biosciences
3 antibodies
Boster Biological Technology
3 antibodies
R&D Systems
1 antibody
Aviva Systems Biology
5 antibodies
Bioworld Technology, Inc
1 antibody
Proteintech Group
1 antibody
Acris Antibodies GmbH
8 antibodies
St John's Laboratory
6 antibodies
Atlas Antibodies
1 antibody
Everest Biotech
1 antibody
ProSci
5 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
BioLegend
4 antibodies
Antibodies.com
2 antibodies
RabMAbs
6 antibodies
Creative Biolabs
15 antibodies
United States Biological
77 antibodies
Creative Diagnostics
8 antibodies
MyBioSource
12 antibodies
Abiocode, Inc.
1 antibody
Cell Signaling Technology, Inc
1 antibody
RayBiotech, Inc.
2 antibodies
Sigma-Aldrich
1 antibody