Tissue expressionAmygdalaBasal gangliaCerebellumCerebral cortexChoroid plexusHippocampal formationHypothalamusMedulla oblongataMidbrainOlfactory bulbPonsSpinal cordThalamusWhite matterRetinaAdrenal glandParathyroid glandPituitary glandThyroid glandLungEsophagusSalivary glandTongueColonDuodenumRectumSmall intestineStomachGallbladderLiverPancreasKidneyUrinary bladderEpididymisProstateSeminal vesicleTestisBreastCervixEndometriumFallopian tubeOvaryPlacentaVaginaHeart muscleSkeletal muscleSmooth muscleAdipose tissueSkinAppendixBone marrowLymph nodeSpleenThymusTonsil02004006008001,000
Cell line expressionAF22GAMGSH-SY5YU-138 MGU-251 MGU-87 MGHTCEpiHTERT-RPE1OE19CACO-2Hep G2CAPAN-2HEK 293NTERA-2RPTEC TERT1RT4PC-3SuSaA-431HaCaTSK-MEL-30WM-115A549HBEC3-KTSCLC-21HAN3-CABEWOEFO-21HeLaHTERT-HME1MCF7SiHaSK-BR-3T-47dHUVEC TERT2TIMEHSkMCASC diffASC TERT1BJBJ hTERT+BJ hTERT+ SV40 Large T+BJ hTERT+ SV40 Large T+ RasG12VFHDF/TERT166HBF TERT88HHSteCLHCN-M2RH-30U-2 OSU-2197DaudiHDLM-2HTEC/SVTERT24-BJURKATKarpas-707MOLT-4REHRPMI-8226U-266/70U-266/84U-698HAP1HELHL-60HMC-1K-562NB-4THP-1U-937050100150200250
Protein structure

ALDH2

Aldehyde dehydrogenase 2 family member
 
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2016]
More gene data

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                        709 antibodies from 42 providers.

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                        WB
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                        Proteintech Group
                        1 antibody
                        antibodies-online
                        210 antibodies
                        GeneTex
                        9 antibodies
                        Invitrogen Antibodies
                        29 antibodies
                        OriGene
                        11 antibodies
                        Novus Biologicals
                        43 antibodies
                        Abnova Corporation
                        10 antibodies
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                        6 antibodies
                        Abcepta
                        11 antibodies
                        Arigo
                        4 antibodies
                        Boster Biological Technology
                        4 antibodies
                        NovoPro Bioscience Inc.
                        13 antibodies
                        Affinity Biosciences
                        3 antibodies
                        Biorbyt
                        32 antibodies
                        HUABIO Research
                        3 antibodies
                        FineTest Biotech
                        1 antibody
                        R&D Systems
                        1 antibody
                        Aviva Systems Biology
                        5 antibodies
                        St John's Laboratory
                        7 antibodies
                        Atlas Antibodies
                        1 antibody
                        Bioworld Technology, Inc
                        1 antibody
                        Antibodies.com
                        13 antibodies
                        Cusabio Biotech Co., Ltd
                        3 antibodies
                        Acris Antibodies GmbH
                        8 antibodies
                        Everest Biotech
                        2 antibodies
                        ProSci
                        5 antibodies
                        Abbkine Scientific Co.Ltd.
                        1 antibody
                        BioLegend
                        4 antibodies
                        RabMAbs
                        6 antibodies
                        Bioss
                        1 antibody
                        Creative Biolabs
                        28 antibodies
                        Abbexa
                        11 antibodies
                        United States Biological
                        77 antibodies
                        Leading Biology
                        14 antibodies
                        MyBioSource
                        12 antibodies
                        Abiocode, Inc.
                        1 antibody
                        Cell Signaling Technology, Inc
                        1 antibody
                        RayBiotech, Inc.
                        2 antibodies
                        MilliporeSigma / Merck KGaA
                        3 antibodies
                        Creative Diagnostics
                        9 antibodies
                        MedChemExpress LLC
                        2 antibodies