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- References [10]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15677-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- LZTS2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LZTS2 antibody (Cat. #15677-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation.
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination.
SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway.
Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway.
RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression.
EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis.
α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2.
Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.
Peneda C, Bugalhao JN, Louro MAD, Henriques-Soares A, Bettencourt-Dias M
Cytoskeleton (Hoboken, N.J.) 2026 Mar;83(3):128-139
Cytoskeleton (Hoboken, N.J.) 2026 Mar;83(3):128-139
The role of SH3RF2 in lung squamous cell carcinoma and M2 polarization: insights into LZTS2 ubiquitination.
Yang J, Jia Z, Li J, Jiang C, Zhao X, Wang Y, Ma X, Xu X
Biology direct 2025 Jul 17;20(1):87
Biology direct 2025 Jul 17;20(1):87
SPOP and HAUSP bidirectionally regulate LZTS2 ubiquitination to modulate the Wnt pathway.
Deng Y, Xie C, Liu R, Ma K, Tang J, Zhou Z
Cell death & disease 2025 Dec 24;17(1):132
Cell death & disease 2025 Dec 24;17(1):132
Phosphorylation of LZTS2 by PLK1 activates the Wnt pathway.
Liu R, Zhou D, Yu B, Zhou Z
Cellular signalling 2024 Aug;120:111226
Cellular signalling 2024 Aug;120:111226
RRP15 deficiency induces ribosome stress to inhibit colorectal cancer proliferation and metastasis via LZTS2-mediated β-catenin suppression.
Dong Z, Li J, Dai W, Yu D, Zhao Y, Liu S, Li X, Zhang Z, Zhang R, Liang X, Kong Q, Jin S, Jiang H, Jiang W, Ding C
Cell death & disease 2023 Feb 7;14(2):89
Cell death & disease 2023 Feb 7;14(2):89
EBV-encoded miRNAs BHRF1-1 and BART2-5p aggravate post- transplant lymphoproliferative disorder via LZTS2-PI3K-AKT axis.
Ji H, Yang T, Li C, Zhu Y, Zheng Z, Zhang J, Liu Y, Gao Y, Wu H, Jiang J, Yong J, Chen M, Tang Y, Xia Q, Xue F
Biochemical pharmacology 2023 Aug;214:115676
Biochemical pharmacology 2023 Aug;214:115676
α-catenin mechanosensitivity as a route to cytokinesis failure through sequestration of LZTS2.
Wang Y, Yemelyanov A, Go CD, Kim S, Quinn JM, Flozak AS, Le PM, Liang S, Claude-Gingras A, Ikura M, Ishiyama N, Gottardi CJ
bioRxiv : the preprint server for biology 2023 Aug 26;
bioRxiv : the preprint server for biology 2023 Aug 26;
Proximity proteomics identifies PAK4 as a component of Afadin-Nectin junctions.
Baskaran Y, Tay FP, Ng EYW, Swa CLF, Wee S, Gunaratne J, Manser E
Nature communications 2021 Sep 7;12(1):5315
Nature communications 2021 Sep 7;12(1):5315
β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S
Oncogene 2021 Feb;40(7):1269-1283
Oncogene 2021 Feb;40(7):1269-1283
LZTS2 inhibits PI3K/AKT activation and radioresistance in nasopharyngeal carcinoma by interacting with p85.
Xu S, Li Y, Lu Y, Huang J, Ren J, Zhang S, Yin Z, Huang K, Wu G, Yang K
Cancer letters 2018 Apr 28;420:38-48
Cancer letters 2018 Apr 28;420:38-48
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 15677-1-AP( LZTS2 Antibody) at dilution of 1:300
- Other comments
- WB
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The LZTS2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human LZTS2. This antibody recognizes human,mouse,rat antigen. The LZTS2 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemistry of paraffin-embedded human kidney tissue slide using 15677-1-AP( LZTS2 Antibody) at dilution of 1:50 (under 10x lens)
- Other comments
- IHC
