344205

antibody from BioLegend

Targeting: ACE ACE1, CD143, DCP1

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

344205

Provider

BioLegend

Proper citation

BioLegend Cat#344205, RRID:AB_11150596

Product name

APC anti-human CD143 (Angiotensin-converting enzyme)

Antibody type

Monoclonal

Antigen

CD143

Description

CD143 (ACE, kininase II, peptidyl dipeptidase 1, peptidase P, carboxycathepsin) is a 171 kD, type I, single chain transmembranal metallopeptidase, whose cofactor is zinc. Its main targets are angiotensin I and bradykinin, acting as a blood pressure regulator. CD143 is expressed in endothelial cells; varying amounts of CD143 have been reported in different epithelial cells. The activation of macrophages and histiocytes induces the expression of this molecule.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

25 tests

Storage

The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

GM-CSF-stimulated human peripheral blood mononuclear cells (day-3) were stained with CD143 (clone 5-369) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram). Data shown was gated on CD14⁺ cell population.

Conjugate

Red dye