Tissue expression
Cell line expression
Protein structure

ACE

Angiotensin I converting enzyme
ACE1, CD143, DCP1 
This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020]
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952 antibodies from 43 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
R&D Systems
25 antibodies
Novus Biologicals
47 antibodies
Proteintech Group
2 antibodies
GeneTex
19 antibodies
antibodies-online
274 antibodies
Invitrogen Antibodies
47 antibodies
OriGene
17 antibodies
NSJ Bioreagents
8 antibodies
Atlas Antibodies
2 antibodies
Boster Biological Technology
8 antibodies
St John's Laboratory
6 antibodies
Biorbyt
75 antibodies
Cusabio Biotech Co., Ltd
8 antibodies
Abnova Corporation
6 antibodies
NovoPro Bioscience Inc.
5 antibodies
Abbiotec
1 antibody
Affinity Biosciences
1 antibody
HUABIO Research
1 antibody
QED Bioscience
1 antibody
Acris Antibodies GmbH
18 antibodies
Aviva Systems Biology
22 antibodies
Bioworld Technology, Inc
2 antibodies
FineTest Biotech
1 antibody
Abgent
5 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Creative Biolabs
42 antibodies
MyBioSource
23 antibodies
RabMAbs
3 antibodies
BioLegend
8 antibodies
Creative Diagnostics
14 antibodies
Arigo
1 antibody
Miltenyi Biotec
6 antibodies
Abbexa
13 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
Abiocode, Inc.
1 antibody
Signalway Antibody LLC
1 antibody
United States Biological
30 antibodies
Leading Biology
6 antibodies
Enzo Life Sciences
2 antibodies
EMD Millipore
1 antibody
ProSci
1 antibody