Tissue expression
Cell line expression

ACE

gene product
ACE1, CD143, DCP1 
This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Antigen sequence

Conjugate

Epitope

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
875 antibodies from 42 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
R&D Systems
25 antibodies
Novus Biologicals
47 antibodies
Proteintech Group
2 antibodies
GeneTex
19 antibodies
antibodies-online
274 antibodies
OriGene
17 antibodies
LifeSpan BioSciences, Inc.
175 antibodies
Boster Biological Technology
8 antibodies
Cusabio Biotech Co., Ltd
8 antibodies
Abnova Corporation
6 antibodies
NovoPro Bioscience Inc.
5 antibodies
Abbiotec
1 antibody
Affinity Biosciences
1 antibody
HUABIO Research
1 antibody
QED Bioscience
1 antibody
Invitrogen Antibodies
29 antibodies
Biorbyt
25 antibodies
Acris Antibodies GmbH
18 antibodies
NSJ Bioreagents
6 antibodies
Atlas Antibodies
2 antibodies
Aviva Systems Biology
22 antibodies
Bioworld Technology, Inc
2 antibodies
Abgent
5 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Wuhan Fine Biotech Co., Ltd.
1 antibody
Creative Biolabs
41 antibodies
MyBioSource
23 antibodies
RabMAbs
3 antibodies
BioLegend
8 antibodies
Creative Diagnostics
14 antibodies
Arigo
1 antibody
Miltenyi Biotec
6 antibodies
Abbexa
13 antibodies
MilliporeSigma / Merck KGaA
5 antibodies
Abiocode, Inc.
1 antibody
Signalway Antibody LLC
1 antibody
United States Biological
30 antibodies
Leading Biology
6 antibodies
Enzo Life Sciences
2 antibodies
EMD Millipore
1 antibody
ProSci
1 antibody