27846-1-AP

antibody from Proteintech Group

Targeting: TANGO2 C22orf25, DKFZp761P1121

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

27846-1-AP

Provider

Proteintech Group

Product name

C22orf25 antibody

Antibody type

Polyclonal

Description

KD/KO validated C22orf25 antibody (Cat. #27846-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

TANGO2 binds crystallin alpha B and its loss causes desminopathy.

Stentenbach M, Hughes LA, Fagan SV, Payne B, Rudler DL, Siira SJ, McCubbin T, Chopin A, Perks KL, Ermer JA, Hendry J, Er TS, Balasubramaniam S, Eliades JA, Hool LC, Packer NH, Moh ESX, Padman BS, Rackham O, Filipovska A
Nature communications 2025 Jun 6;16(1):5261

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Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH.

Jayaram DT, Sivaram P, Biswas P, Dai Y, Sweeny EA, Stuehr DJ
Nature communications 2025 Aug 26;16(1):7972

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Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.

Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, Perez W, Sun L, Yu AC, Kim JJ, Lalani SR, Li N, Horrigan FT, Altamirano F, Wehrens XH, Miyake CY, Zhang L
JCI insight 2024 Jun 10;9(11)

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TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning.

de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Guillou EL, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P
Autophagy reports 2024 Dec 31;3(1)

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Intrinsic and extrinsic regulation of rhabdomyolysis susceptibility by Tango2.

Kim ES, Casey JG, Tao BS, Mansur A, Mathiyalagan N, Wallace ED, Ehrmann BM, Gupta VA
Disease models & mechanisms 2023 Sep 1;16(9)

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HRG-9 homologues regulate haem trafficking from haem-enriched compartments.

Sun F, Zhao Z, Willoughby MM, Shen S, Zhou Y, Shao Y, Kang J, Chen Y, Chen M, Yuan X, Hamza I, Reddi AR, Chen C
Nature 2022 Oct;610(7933):768-774

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The phenotype associated with variants in TANGO2 may be explained by a dual role of the protein in ER-to-Golgi transport and at the mitochondria.

Milev MP, Saint-Dic D, Zardoui K, Klopstock T, Law C, Distelmaier F, Sacher M
Journal of inherited metabolic disease 2021 Mar;44(2):426-437

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Clinical and biological characterization of 20 patients with TANGO2 deficiency indicates novel triggers of metabolic crises and no primary energetic defect.

Bérat CM, Montealegre S, Wiedemann A, Nuzum MLC, Blondel A, Debruge H, Cano A, Chabrol B, Hoebeke C, Polak M, Stoupa A, Feillet F, Torre S, Boddaert N, Bruel H, Barth M, Damaj L, Abi-Wardé MT, Afenjar A, Benoist JF, Madrange M, Caccavelli L, Renard P, Hubas A, Nusbaum P, Pontoizeau C, Gobin S, van Endert P, Ottolenghi C, Maltret A, de Lonlay P
Journal of inherited metabolic disease 2021 Mar;44(2):415-425